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  • Journal article
    STYRING S, MIYAO M, RUTHERFORD AW, 1987,

    FORMATION AND FLASH-DEPENDENT OSCILLATION OF THE S2-STATE MULTILINE ELECTRON-PARAMAGNETIC-RES SIGNAL IN AN OXYGEN-EVOLVING PHOTOSYSTEM-II PREPARATION LACKING THE 3 EXTRINSIC PROTEINS IN THE OXYGEN-EVOLVING SYSTEM

    , BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 890, Pages: 32-38, ISSN: 0006-3002
  • Journal article
    Bryant SH, Sternberg MJE, 1987,

    Colour plates

    , Journal of Molecular Graphics, Vol: 5, Pages: 25-28, ISSN: 0263-7855
  • Journal article
    Taylor ME, Leaning MS, Summerfield JA, 1987,

    Uptake and processing of glycoproteins by rat hepatic mannose receptor

    , American Journal of Physiology - Endocrinology and Metabolism, Vol: 252, ISSN: 0193-1849

    A linear compartmental model has been developed for the in vivo metabolism of glycoproteins. The model is applied to the interpretation of dynamic data from the rat on agalactoorosomucoid (AGOR), an N-acetylglucosamine (GlcNAc)-terminated glycoprotein, and three neoglycoproteins terminating in mannose [mannose36-bovine serum albumin (Man-BSA)] or glucose [maltose29-BSA (Mal29-BSA) and maltose8-BSA (Mal8-BSA)]. All of these proteins are taken up by the Man/GlcNAc receptor on hepatic sinusoidal cells. The rate of uptake was found to be determined by sugar type (Man-BSA, 0.78 min-1 > Mal29-BSA, 0.13 min-1), sugar density (Mal29-BSA > Mal8-BSA), and the geometry of the sugar display (AGOR, 0.51 min-1 > Mal29-BSA). Intracellular transport from the cell membrane to the lysosomes was slower for Man-BSA (~3 min) than for the other ligands (~0 min), suggesting that receptor-ligand uncoupling was slower for Man-BSA for which the receptor had the highest affinity or that extralysosomal catabolism of the other ligands occurred. Catabolism was also determined by the carbohydrate moiety of the ligand; it was greater for Mal29-BSA and Mal8-BSA (≥0.8 min-1) than for Man-BSA (0.27 min-1), and AGOR, with a complex oligosaccharide, was most resistant to degradation (0.14 min-1). An understanding of these structural features of glycoproteins that influence hepatic uptake, transport, and catabolism will be of value in drug targeting and for enzyme replacement in lysosomal storage disorders. Special emphasis is placed on model identifiability before experimentation as an aid in experiment design.
  • Journal article
    Mathis P, Rutherford AW, 1987,

    The Primary Reactions of Photosystems I and II of Algae and Higher Plants

    , New Comprehensive Biochemistry, Vol: 15, Pages: 63-96, ISSN: 0167-7306

    This chapter discusses the primary reactions of photosystems I and II of algae and higher plants. In photosynthetic organisms, the “primary reactions” fulfil the objective of converting the energy of light into a primary form of chemical energy which lasts for a time compatible with ordinary biochemical processes—that is, milliseconds. In these reactions, a rather large fraction, approximately 40%, of the photon energy is stored as chemical free energy. The primary reactions can be viewed from two major perspectives. Firstly, from a photochemical point of view: pigment molecules are excited to their lowest excited singlet state, which reacts in an electron transfer reaction, the first step of a process of charge separation. Secondly, from a biochemical point of view the reactions take place in highly organized complexes, the reaction centres, which are made up of several classes of molecules that cooperate in fulfilling complementary roles, such as: architectural support, light absorption, energy transfer and electron transfer. All oxygenic organisms, ranging from cyanobacteria to algae and higher plants, contain photosystem I (PS I) and PS II reaction centres, with only minor variations in spite of their large taxonomic and ecological diversity. © 1987, Elsevier B.V. All rights reserved.
  • Journal article
    DIMARZO V, TIPPINS JR, MORRIS HR, 1987,

    NEUROPEPTIDES AND LEUKOTRIENE RELEASE - EFFECT OF PEPTIDE HISTIDINE ISOLEUCINE AND SECRETIN IN PLATELET ACTIVATING FACTOR-STIMULATED RAT LUNG

    , NEUROPEPTIDES, Vol: 9, Pages: 51-58, ISSN: 0143-4179
  • Journal article
    Rees MC, Di Marzo V, Tippins JR, Morris HR, Turnbull ACet al., 1987,

    Leukotriene release by nonpregnant human endometrium and myometrium.

    , Adv Prostaglandin Thromboxane Leukot Res, Vol: 17B, Pages: 1125-1128, ISSN: 0732-8141
  • Journal article
    HD Williams, 1987,

    Reduction of iron (III) by Escherichia coli K12: Lack of involvement of respiratory chains

    , Current Microbiology, Vol: 15, Pages: 319-324
  • Journal article
    MARDER JB, CHAPMAN DJ, TELFER A, NIXON PJ, BARBER Jet al., 1987,

    IDENTIFICATION OF PSBA AND PSBD GENE-PRODUCTS, D1 AND D2, AS REACTION CENTER PROTEINS OF PHOTOSYSTEM-2

    , PLANT MOLECULAR BIOLOGY, Vol: 9, Pages: 325-333, ISSN: 0167-4412
  • Journal article
    Hartley DA, Xu T, Artavanis-Tsakonas S, 1987,

    The embryonic expression of the Notch locus of Drosophila melanogaster and the implications of point mutations in the extracellular EGF-like domain of the predicted protein

    , EMBO Journal, Vol: 7, Pages: 3917-3927
  • Journal article
    Franks NP, Lieb WR, 1987,

    Are the biological effects of ethanol due to primary interactions with lipids or with proteins?

    , Alcohol Alcohol Suppl, Vol: 1, Pages: 139-145, ISSN: 1358-6173

    The biological effects of ethanol and other simple organic molecules have traditionally been ascribed to their actions on the lipid portions of biological membranes. However, at the concentrations at which these molecules exert their pharmacological effects in man and other animals, changes in the structure and fluidity of lipid bilayers are extremely small and can be mimicked by a change in temperature of only about 1 degree C. On the other hand, we have found that the activity of a soluble protein can be markedly affected at these concentrations. Indeed, the concentrations of general anaesthetics which half-inhibit the activity of this enzyme are essentially identical to those which cause general anaesthesia in animals. The evidence thus suggests that ethanol and other simple molecules act directly on proteins rather than lipids.
  • Journal article
    HD Williams, RK Poole, 1987,

    The cytochromes of Acetobacter pasteurianus NCIB 6428. Evidence of a role for a cytochrome a1-like haemoprotein in electron transfer to cytochrome oxidase d.

    , Journal of General Microbiology, Vol: 133, Pages: 2461-2472
  • Journal article
    RK Poole, HD Williams, 1987,

    Proposal that the function of the membrane-bound cytochrome a1-like haemoprotein (cytochrome b595) in Escherichia coli is direct electron donation to cytochrome d

    , FEBS Letters, Vol: 217, Pages: 49-52
  • Journal article
    ZAIDI M, CHAMBERS TJ, TIPPINS J, MORRIS HR, MACINTYRE Iet al., 1987,

    STRUCTURAL MODIFICATIONS OF HUMAN CGRP AND THEIR EFFECT ON OSTEOCLASTIC BONE-RESORPTION

    , BONE, Vol: 8, Pages: 265-265, ISSN: 8756-3282
  • Journal article
    HD Williams, RK Poole, 1987,

    Low temperature spectrophotometric studies of cytochromes a1 and d in Acetobacter pasteurianus (NCIB 6428)

    , Biochemical Society Transactions, Vol: 14, Pages: 1215-1216
  • Journal article
    Gleispach H, Malle E, Dadak C, Hohenester E, Wurm H, Leis HJet al., 1987,

    Profiling prostaglandins, thromboxanes and hydroxy fatty acids using stable isotope dilutions and gas chromatography-mass spectrometry.

    , Prog Clin Biol Res, Vol: 242, Pages: 7-12, ISSN: 0361-7742
  • Journal article
    Tippins JR, Di Marzo V, Morris HR, 1987,

    Effect of vasoactive intestinal peptide and calcitonin gene-related peptide on leukotriene release from guinea pig and rat lung.

    , Adv Prostaglandin Thromboxane Leukot Res, Vol: 17B, Pages: 1028-1032, ISSN: 0732-8141
  • Journal article
    NIXON PJ, DYER TA, BARBER J, HUNTER CNet al., 1986,

    IMMUNOLOGICAL EVIDENCE FOR THE PRESENCE OF THE D 1-PROTEIN AND D 2-PROTEIN IN PS-II CORES OF HIGHER-PLANTS

    , FEBS LETTERS, Vol: 209, Pages: 83-86, ISSN: 0014-5793
  • Journal article
    Franks NP, Lieb WR, 1986,

    Mapping of general anaesthetic target sites (reply)

    , Nature, Vol: 319, ISSN: 0028-0836
  • Journal article
    VERMAAS WFJ, WILLIAMS JGK, RUTHERFORD AW, MATHIS P, ARNTZEN CJet al., 1986,

    GENETICALLY ENGINEERED MUTANT OF THE CYANOBACTERIUM SYNECHOCYSTIS 6803 LACKS THE PHOTOSYSTEM-II CHLOROPHYLL-BINDING PROTEIN CP-47

    , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 83, Pages: 9474-9477, ISSN: 0027-8424
  • Journal article
    DIMARZO V, TIPPINS JR, MORRIS HR, 1986,

    THE EFFECT OF VASOACTIVE-INTESTINAL-PEPTIDE AND CALCITONIN GENE-RELATED PEPTIDE ON PEPTIDOLEUKOTRIENE RELEASE FROM PLATELET-ACTIVATING-FACTOR STIMULATED RAT LUNGS AND IONOPHORE STIMULATED GUINEA-PIG LUNGS

    , BIOCHEMISTRY INTERNATIONAL, Vol: 13, Pages: 933-942, ISSN: 0158-5231
  • Journal article
    MILLNER PA, MARDER JB, GOUNARIS K, BARBER Jet al., 1986,

    LOCALIZATION AND IDENTIFICATION OF PHOSPHOPROTEINS WITHIN THE PHOTOSYSTEM-II CORE OF HIGHER-PLANT THYLAKOID MEMBRANES

    , BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 852, Pages: 30-37, ISSN: 0006-3002
  • Journal article
    STERNBERG MJE, 1986,

    PREDICTION OF PROTEIN-STRUCTURE FROM AMINO-ACID-SEQUENCE

    , ANTI-CANCER DRUG DESIGN, Vol: 1, Pages: 169-178, ISSN: 0266-9536
  • Journal article
    PETRILLI P, PUCCI P, MORRIS HR, ADDEO Fet al., 1986,

    ASSIGNMENT OF PHOSPHORYLATION SITES IN BUFFALO BETA-CASEIN BY FAST-ATOM-BOMBARDMENT MASS-SPECTROMETRY

    , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 140, Pages: 28-37, ISSN: 0006-291X
  • Journal article
    VOLKER M, RENGER G, RUTHERFORD AW, 1986,

    EFFECTS OF TRYPSIN UPON ELECTRON-PARAMAGNETIC-RES SIGNALS ARISING FROM COMPONENTS OF THE DONOR SIDE OF PHOTOSYSTEM-II

    , BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 851, Pages: 424-430, ISSN: 0006-3002
  • Journal article
    ZIMMERMANN JL, RUTHERFORD AW, 1986,

    PHOTOREDUCTANT-INDUCED OXIDATION OF FE-2+ IN THE ELECTRON-ACCEPTOR COMPLEX OF PHOTOSYSTEM-II

    , BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 851, Pages: 416-423, ISSN: 0006-3002
  • Journal article
    PRENTICE IC, 1986,

    VEGETATION RESPONSES TO PAST CLIMATIC VARIATION

    , VEGETATIO, Vol: 67, Pages: 131-141, ISSN: 0042-3106
  • Journal article
    BRAIN SD, TIPPINS JR, MORRIS HR, MACINTYRE I, WILLIAMS TJet al., 1986,

    POTENT VASODILATOR ACTIVITY OF CALCITONIN GENE-RELATED PEPTIDE IN HUMAN-SKIN

    , JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol: 87, Pages: 533-536, ISSN: 0022-202X
  • Journal article
    Ono T, Zimmermann JL, Inoue Y, Rutherford AWet al., 1986,

    EPR evidence for a modified S-state transition in chloride-depleted Photosystem II

    , BBA - Bioenergetics, Vol: 851, Pages: 193-201, ISSN: 0005-2728

    The role of chloride on the S-state transition in spinach Photosystem II (PS II) particles was investigated by EPR spectroscopy at low temperature and the following results were obtained. (1) After excitation by continuous light at 200 K, chloride-depleted particles did not show the EPR multiline signal associated with the S2 state, but only showed the broad signal at g = 4.1. The S2 multiline signal was completely restored upon chloride repletion. (2) In the absence of chloride the S2 multiline signal was not induced by a single flash excitation at 0°C. However, upon addition of chloride after the flash the signal was developed in darkness. (3) The amplitude of the multiline S2 signal thus developed upon chloride addition after flash illumination did not show oscillations dependent upon flash number. These results indicate that the O2-evolving complex in chloride-depleted PS II membranes is able to store at least one oxidizing equivalent, a modified S2 state, which does not give rise to the multiline signal. Addition of chloride converts this oxidizing equivalent to the normal S2 state which gives rise to the multiline signal. The modified S2 state is more stable than the normal S2 state, showing decay kinetics about 20-times slower than those of the normal S2 state, and the formation of higher S states is blocked. © 1986.
  • Journal article
    ONO T, ZIMMERMANN JL, INOUE Y, RUTHERFORD AWet al., 1986,

    ELECTRON-PARAMAGNETIC-RES EVIDENCE FOR A MODIFIED S-STATE TRANSITION IN CHLORIDE-DEPLETED PHOTOSYSTEM-II

    , BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 851, Pages: 193-201, ISSN: 0006-3002
  • Journal article
    MORRIS HR, 1986,

    RECOMBINANT PROTEIN-ANALYSIS BY HIGH-FIELD FAB MASS-SPECTROMETRY

    , ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol: 192, Pages: 54-ANYL, ISSN: 0065-7727

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