@article{Olechnowicz:2024:10.3390/ijms25042176,
author = {Olechnowicz, A and Blatkiewicz, M and Jopek, K and Isalan, M and Mielcarek, M and Rucinski, M},
doi = {10.3390/ijms25042176},
journal = {International Journal of Molecular Sciences},
title = {Deregulated transcriptome as a platform for adrenal Huntington’s disease-related pathology},
url = {http://dx.doi.org/10.3390/ijms25042176},
volume = {25},
year = {2024}
}

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TY  - JOUR
AB  - Huntington’s disease (HD) is a neurodegenerative disorder that affects mainly the central nervous system (CNS) by inducing progressive deterioration in both its structure and function. In recent years, there has been growing interest in the impact of HD on peripheral tissue function. Herein, we used the R6/2 mouse model of HD to investigate the influence of the disease on adrenal gland functioning. A transcriptomic analysis conducted using a well-established quantitative method, an Affymetrix array, revealed changes in gene expression in the R6/2 model compared to genetic background controls. For the first time, we identified disruptions in cholesterol and sterol metabolism, blood coagulation, and xenobiotic metabolism in HD adrenal glands. This study showed that the disrupted expression of these genes may contribute to the underlying mechanisms of Huntington’s disease. Our findings may contribute to developing a better understanding of Huntington’s disease progression and aid in the development of novel diagnostic or therapeutic approaches.
AU  - Olechnowicz,A
AU  - Blatkiewicz,M
AU  - Jopek,K
AU  - Isalan,M
AU  - Mielcarek,M
AU  - Rucinski,M
DO  - 10.3390/ijms25042176
PY  - 2024///
SN  - 1422-0067
TI  - Deregulated transcriptome as a platform for adrenal Huntington’s disease-related pathology
T2  - International Journal of Molecular Sciences
UR  - http://dx.doi.org/10.3390/ijms25042176
UR  - http://hdl.handle.net/10044/1/110022
VL  - 25
ER  - 

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