BibTex format
@article{Alasmari:2024:10.1183/13993003.02353-2022,
author = {Alasmari, AM and Alsulayyim, AS and Alghamdi, SM and Philip, KEJ and Buttery, SC and Banya, WAS and Polkey, MI and Armstrong, PC and Rickman, MJ and Warner, TD and Mitchell, JA and Hopkinson, NS},
doi = {10.1183/13993003.02353-2022},
journal = {European Respiratory Journal},
title = {Oral nitrate supplementation improves cardiovascular risk markers in COPD: ON-BC, a randomised controlled trial},
url = {http://dx.doi.org/10.1183/13993003.02353-2022},
volume = {63},
year = {2024}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BACKGROUND: Short-term studies suggest that dietary nitrate (NO3 -) supplementation may improve the cardiovascular risk profile, lowering blood pressure (BP) and enhancing endothelial function. It is not clear if these beneficial effects are sustained and whether they apply in people with COPD, who have a worse cardiovascular profile than those without COPD. Nitrate-rich beetroot juice (NR-BRJ) is a convenient dietary source of nitrate. METHODS: The ON-BC trial was a randomised, double-blind, placebo-controlled parallel group study in stable COPD patients with home systolic BP (SBP) measurement ≥130mmHg. Participants were randomly allocated (1:1) using computer-generated, block randomisation to either 70mL NR-BRJ (400mg NO3 -) (n=40) or an otherwise identical nitrate-depleted placebo juice (0mg NO3 -) (n=41), once daily for 12weeks. The primary end-point was between-group change in home SBP measurement. Secondary outcomes included change in 6-min walk distance (6MWD) and measures of endothelial function (reactive hyperaemia index (RHI) and augmentation index normalised to a heart rate of 75beats·min-1 (AIx75)) using an EndoPAT device. Plasma nitrate and platelet function were also measured. RESULTS: Compared with placebo, active treatment lowered SBP (Hodges-Lehmann treatment effect -4.5 (95% CI -5.9- -3.0)mmHg), and improved 6MWD (30.0 (95% CI 15.7-44.2)m; p<0.001), RHI (0.34 (95% CI 0.03-0.63); p=0.03) and AIx75 (-7.61% (95% CI -14.3- -0.95%); p=0.026). CONCLUSIONS: In people with COPD, prolonged dietary nitrate supplementation in the form of beetroot juice produces a sustained reduction in BP, associated with an improvement in endothelial function and exercise capacity.
AU - Alasmari,AM
AU - Alsulayyim,AS
AU - Alghamdi,SM
AU - Philip,KEJ
AU - Buttery,SC
AU - Banya,WAS
AU - Polkey,MI
AU - Armstrong,PC
AU - Rickman,MJ
AU - Warner,TD
AU - Mitchell,JA
AU - Hopkinson,NS
DO - 10.1183/13993003.02353-2022
PY - 2024///
SN - 0903-1936
TI - Oral nitrate supplementation improves cardiovascular risk markers in COPD: ON-BC, a randomised controlled trial
T2 - European Respiratory Journal
UR - http://dx.doi.org/10.1183/13993003.02353-2022
UR - https://www.ncbi.nlm.nih.gov/pubmed/38123239
VL - 63
ER -