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@article{Abdolmohammadi-Vahid:2024:10.1016/j.intimp.2024.112419,
author = {Abdolmohammadi-Vahid, S and Baradaran, B and Adcock, I and Mortaz, E},
doi = {10.1016/j.intimp.2024.112419},
journal = {International Immunopharmacology},
title = {Immune checkpoint inhibitors and SARS-CoV2 infection},
url = {http://dx.doi.org/10.1016/j.intimp.2024.112419},
volume = {137},
year = {2024}
}
TY - JOUR
AB - Infection with severe acute respiratory syndrome coronavirus 2 (SARSCoV2) triggers coronavirus disease 2019 (COVID-19), which predominantly targets the respiratory tract. SARS-CoV-2 infection, especially severe COVID-19, is associated with dysregulated immune responses against the virus, including exaggerated inflammatory responses known as the cytokine storm, together with lymphocyte and NK cell dysfunction known as immune cell exhaustion. Overexpression of negative immune checkpoints such as PD-1 and CTLA-4 plays a considerable role in the dysfunction of immune cells upon SARS-CoV-2 infection. Blockade of these checkpoints has been suggested to improve the clinical outcome of COVID-19 patients by promoting potent immune responses against the virus. In the current review, we provide an overview of the potential of checkpoint inhibitors to induce potent immune responses against SARS-CoV-2 and improving the clinical outcome of severe COVID-19 patients.
AU - Abdolmohammadi-Vahid,S
AU - Baradaran,B
AU - Adcock,I
AU - Mortaz,E
DO - 10.1016/j.intimp.2024.112419
PY - 2024///
SN - 1567-5769
TI - Immune checkpoint inhibitors and SARS-CoV2 infection
T2 - International Immunopharmacology
UR - http://dx.doi.org/10.1016/j.intimp.2024.112419
VL - 137
ER -