In this section
@inbook{Donnelly:2024:10.1183/2312508X.10006423,
author = {Donnelly, L and Devulder, J},
booktitle = {COPD in the 21st Century},
doi = {10.1183/2312508X.10006423},
editor = {Wedzicha and Allinson and Calverley},
pages = {100--117},
publisher = {ERS},
title = {Mechanisms and Mediatiors of Disease},
url = {http://dx.doi.org/10.1183/2312508X.10006423},
year = {2024}
}
TY - CHAP
AB - COPD is a common respiratory condition characterised by airway limitation and changes in airway structure. There is currently no curative treatment for COPD and there is an urgent unmet need for new therapeutics that could modify the course of the disease. The mechanisms underlying COPD pathology are complex and are composed of chronic inflammatory processes, oxidative stress induced by continued exposure of the lungs to harmful particles and accelerated ageing due to an increased number of senescent cells within the airways. The main challenge of current studies is to explore how these underlying mechanisms coalesce to drive disease pathophysiology. This chapter aims to describe recent developments in our understanding of COPD mechanisms, from the inflammatory response to the induction of cellular senescence in the lung. Understanding these mechanisms may result in the development of new therapeutics that could be effective for COPD but also for other age-related diseases.
AU - Donnelly,L
AU - Devulder,J
DO - 10.1183/2312508X.10006423
EP - 117
PB - ERS
PY - 2024///
SP - 100
TI - Mechanisms and Mediatiors of Disease
T1 - COPD in the 21st Century
UR - http://dx.doi.org/10.1183/2312508X.10006423
ER -