In this section
@article{Hopkinson:2025,
author = {Hopkinson, N and Polkey, M and Price, L and McCabe, C and Alasmari, A and Al, Sulayyim A and Alghamdi, S and Hudson, S and Rickman, M and Mitchell, J and Ahmetaj-Shala, B},
journal = {Thorax},
pages = {335--338},
title = {Dietary nitrate supplementation enhances exercise capacity in WHO Group 3 pulmonary hypertension: a double-blind, placebo-controlled, randomised crossover study (EDEN-OX2)},
volume = {80},
year = {2025}
}
TY - JOUR
AB - Dietary nitrate supplementation, which improves skeletal muscle oxygen utilisation, vascular endothelial function and exercise capacity in people with chronic obstructive pulmonary disease, may benefit other lung conditions. In a double-blind, placebo-controlled, crossover study, in 19 adults with Group 3 pulmonary hypertension who desaturated during exercise, 140 mL of nitrate-rich beetroot juice improved endurance shuttle walk time compared with nitrate-depleted beetroot juice placebo (median (IQR) ESWT NR-BRJ 197 (140–273) s vs PL-BRJ 174 (107–229) s; median difference (MD) (95% CI) 30 (6.19 to 91.07) s, p=0.0281), endothelial function, flow-mediated dilatation (+3.40±5.47% vs −1.33±4.78; MD (95% CI) 4.73 (1.44 to 8.02), p=0.007) and lowered mean arterial blood pressure (−3.9 (−7.4 to −0.4) mm Hg, p=0.028).
AU - Hopkinson,N
AU - Polkey,M
AU - Price,L
AU - McCabe,C
AU - Alasmari,A
AU - Al,Sulayyim A
AU - Alghamdi,S
AU - Hudson,S
AU - Rickman,M
AU - Mitchell,J
AU - Ahmetaj-Shala,B
EP - 338
PY - 2025///
SN - 0040-6376
SP - 335
TI - Dietary nitrate supplementation enhances exercise capacity in WHO Group 3 pulmonary hypertension: a double-blind, placebo-controlled, randomised crossover study (EDEN-OX2)
T2 - Thorax
VL - 80
ER -