BibTex format
@article{Kuks:2025:10.1183/23120541.00616-2024,
author = {Kuks, PJM and Kole, TM and Kraft, M and Siddiqui, S and Fabbri, LM and Rabe, KF and Papi, A and Brightling, C and Singh, D and van, der Molen T and Kocks, JWWH and Chung, KF and Adcock, IM and Bhavsar, PK and Kermani, NZ and Heijink, IH and Pouwels, SD and Kerstjens, HAM and Slebos, D-J and van, den Berge M},
doi = {10.1183/23120541.00616-2024},
journal = {ERJ Open Research},
pages = {00616--2024},
title = {Neutrophilic inflammation in sputum or blood does not define a clinically distinct asthma phenotype in ATLANTIS},
url = {http://dx.doi.org/10.1183/23120541.00616-2024},
volume = {11},
year = {2025}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - IntroductionNeutrophilic asthma has been suggested to be a clinically distinct phenotype characterised by more severe airflow obstruction and higher exacerbation risk. However, this has only been assessed in few and smaller studies, using different cut-offs to define neutrophilia, and with conflicting results. We used data from ATLANTIS, an observational longitudinal study including a large number of patients with asthma and healthy controls. The aim of the present study was to examine whether neutrophilic inflammation, either in sputum or blood, is more prevalent in asthma and whether it correlates with disease severity.MethodsATLANTIS included 773 asthma patients, with blood collected from 767 (99%) and sputum from 228 patients (30%). Data were available from 244 healthy controls, all providing blood and 126 (52%) providing sputum. Asthma patients were characterised, including parameters of large and small airways disease at baseline and after 6 and 12months of follow-up. Sputum and blood neutrophilia were defined as values exceeding the upper quartile in asthma patients.ResultsThe prevalence of sputum neutrophilia did not differ between asthma patients and healthy controls. Asthma patients with sputum neutrophilia did not display more severe symptoms, large or small airways disease or more frequent exacerbations. Blood neutrophilia was more common in asthma and was associated with higher body mass index, female sex, current smoking and systemic corticosteroid use. Patients with blood neutrophilia had a statistically significant, but small, increase in residual volume/total lung capacity. Blood neutrophilia was not associated with large or small airways disease or exacerbation risk.ConclusionSputum and blood neutrophilia do not define a distinct clinical phenotype in asthma.
AU - Kuks,PJM
AU - Kole,TM
AU - Kraft,M
AU - Siddiqui,S
AU - Fabbri,LM
AU - Rabe,KF
AU - Papi,A
AU - Brightling,C
AU - Singh,D
AU - van,der Molen T
AU - Kocks,JWWH
AU - Chung,KF
AU - Adcock,IM
AU - Bhavsar,PK
AU - Kermani,NZ
AU - Heijink,IH
AU - Pouwels,SD
AU - Kerstjens,HAM
AU - Slebos,D-J
AU - van,den Berge M
DO - 10.1183/23120541.00616-2024
EP - 2024
PY - 2025///
SN - 2312-0541
SP - 00616
TI - Neutrophilic inflammation in sputum or blood does not define a clinically distinct asthma phenotype in ATLANTIS
T2 - ERJ Open Research
UR - http://dx.doi.org/10.1183/23120541.00616-2024
UR - https://doi.org/10.1183/23120541.00616-2024
VL - 11
ER -