BibTex format
@article{de:2025:10.1016/j.rmed.2025.108553,
author = {de, Santana MBR and Cruz, ÁA and de, Araújo JLF and Tugores, RM and Teixeira, HMP and de, Jesus TS and Pimentel, G and Santana, CVN and Kermani, NZ and Chung, KF and Adcock, IM and Souza-Machado, A and Figueiredo, CA and Dos, Santos Costa R},
doi = {10.1016/j.rmed.2025.108553},
journal = {Respir Med},
title = {Variants in the Glucocorticoid Receptor gene (NR3C1), asthma control and serum cytokine levels.},
url = {http://dx.doi.org/10.1016/j.rmed.2025.108553},
year = {2025}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - INTRODUCTION: Asthma is a heterogeneous disease usually treated with inhaled corticosteroids (ICS) and long-acting beta2 agonists. However, not all individuals achieve adequate control with ICS. AIM: To identify genetic variants in the glucocorticoid receptor gene (NR3C1) associated with asthma endophenotypes, bronchodilator reversibility, and asthma control under medium-to-high ICS doses. METHODS: Association analyses were performed in 365 patients with moderate-to-severe asthma, 383 with mild asthma, and 330 non-asthmatic individuals. Asthma severity was defined by the need for regular treatment with medium-to-high ICS doses. Bronchodilator reversibility was defined as an increase of ≥200 ml and ≥12% in FEV1 from baseline. Asthma control was assessed using the ACQ6 score. Serum cytokine concentrations were measured with Luminex. RESULTS: The A allele of rs2918417 was associated with reduced risk of moderate-to-severe asthma (OR: 0.50; 95% CI: 0.26-0.98) and fewer exacerbations (OR: 0.54; 95% CI: 0.30-0.96); GA/AA genotypes showed lower IL-8 and IL-13 levels compared to GG. The G allele of rs6877893 decreased the risk of uncontrolled asthma in the recessive model (OR: 0.53; 95% CI: 0.29-0.98), with GG carriers showing reduced IL-17A. Conversely, the A allele of rs4585488 increased risk of uncontrolled asthma (OR: 4.42; 95% CI: 1.06-18.48), and the C allele of rs4912650 was linked to poor control (OR: 1.64; 95% CI: 1.01-2.69). The G allele of rs4607376 was associated with lack of bronchodilator reversibility (OR: 1.51; 95% CI: 1.05-2.17) and asthma exacerbations (OR: 1.37; 95% CI: 1.01-1.87). CONCLUSIONS: NR3C1 variants are associated with moderate-to-severe asthma, poor control, lack of bronchodilator reversibility, and differential cytokine profiles.
AU - de,Santana MBR
AU - Cruz,ÁA
AU - de,Araújo JLF
AU - Tugores,RM
AU - Teixeira,HMP
AU - de,Jesus TS
AU - Pimentel,G
AU - Santana,CVN
AU - Kermani,NZ
AU - Chung,KF
AU - Adcock,IM
AU - Souza-Machado,A
AU - Figueiredo,CA
AU - Dos,Santos Costa R
DO - 10.1016/j.rmed.2025.108553
PY - 2025///
TI - Variants in the Glucocorticoid Receptor gene (NR3C1), asthma control and serum cytokine levels.
T2 - Respir Med
UR - http://dx.doi.org/10.1016/j.rmed.2025.108553
UR - https://www.ncbi.nlm.nih.gov/pubmed/41352569
ER -