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@article{Button:2025:10.1183/2312508X.10026924,
author = {Button, B and Chung, KF and Edwards, DA},
doi = {10.1183/2312508X.10026924},
journal = {Ers Monograph},
pages = {83--93},
title = {Airway mucosal mediation of chronic cough and cough hypersensitivity},
url = {http://dx.doi.org/10.1183/2312508X.10026924},
volume = {2025-December},
year = {2025}
}
TY - JOUR
AB - Cough plays a critical role in the clearance of mucus in respiratory disease. Recent findings suggest that mucus may also play a key role in the origins of cough itself. Recent in vitro and in vivo studies indicate that protracted mucosal collapse or intermittent collapse over long periods of tidal breathing can initiate an inflammatory cascade that triggers cough by multiple pathways, upregulating the expression of genes associated with cough hypersensitivity. Recent clinical data in RCC patients, and experimental data collected in airway lining interface cultures of human bronchial epithelial cells, indicate that reversing mucosal collapse with salt ions and buffers endogenous to the airways, while mimicking airway surface liquid pH fluctuations that occur in healthy human airways, diminishes airway epithelial cell compression, reduces cough frequency in RCC, and potentially lessens cough hypersensitivity.
AU - Button,B
AU - Chung,KF
AU - Edwards,DA
DO - 10.1183/2312508X.10026924
EP - 93
PY - 2025///
SN - 2312-508X
SP - 83
TI - Airway mucosal mediation of chronic cough and cough hypersensitivity
T2 - Ers Monograph
UR - http://dx.doi.org/10.1183/2312508X.10026924
VL - 2025-December
ER -