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• Journal article
  Yang F, McDowell R, Busby J, Murphy AC, Patel PH, Jackson D, Mansur AH, Pfeffer PE, Pantin T, Gore R, Brown T, Naveed S, Burhan H, Patel M, Idris E, Pavord I, Subramanian D, Dodd JW, Rupani H, Chaudhuri R, Vyas A, Faruqi S, Sammut D, Message S, Masoli M, Bloom CI, Heaney LG, Siddiqui Set al., 2025,

  Pre-biologic assessment of adherence in severe asthma and association with biologic continuation: a UK Severe Asthma Registry Study

  , BMJ Open Respiratory Research, Vol: 12, ISSN: 2052-4439

  Background Biologic therapies are approved for uncontrolled severe asthma despite good adherence to inhaled corticosteroids (ICS) and additional controllers. We examined the adherence assessments used across UK Severe Asthma Centres (SACs) and their relationship with biologic continuation and response.Methods UK SACs completed a quantitative survey on adherence assessment practices in 2022. We included all adult patients with severe asthma patients on ICS starting biologic therapy from the UK Severe Asthma Registry, which collects pre-biologic adherence data, including medication possession ratio (MPR), fractional exhaled nitric oxide (FeNO) suppression testing and serum prednisolone levels. Biologic continuation and response were defined as continuation on any biologic and the same biologic after 1 year, respectively. Associations were determined using multivariable logistic regression.Results At 21 SACs, MPR for ICS was assessed at 19 (90%) centres, prednisolone and/or cortisol levels in patients on daily oral corticosteroids at 15 (71%), and FeNO suppression testing at 9 (43%). Of 3307 biologic-initiated patients, 1943 (59%) had MPR for ICS recorded, of which 1802 (93%) demonstrated good adherence (≥75% MPR). Only 110 (9%) and 272 (16%) had FeNO suppression and serum prednisolone results, respectively. Good ICS adherence was associated with 2.65-fold higher odds (95% CI 1.02 to 6.91) of biologic continuation, but not with biologic response (OR 1.37, 95% CI 0.50 to 3.76).Conclusion Good pre-biologic ICS adherence, measured using MPR, is associated with biologic continuation at 1 year. Further research is needed to determine whether baseline adherence predicts biologic response based on clinical and biologic criteria.

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• Journal article
  Zhou X-H, Prothon S, Liathdale E, Ferrari N, Hezaveh K, Liu Z, Nemes S, Almquist J, Williams ML, Sobande O, Gottfridsson C, Gochuico BR, Platt A, Brohawn Z, Belvisi MG, Goldwater R, Hornberg E, Owen CAet al., 2025,

  A phase 1 study evaluating the safety, tolerability, and pharmacokinetics of the porcupine inhibitor, AZD5055

  , ISCIENCE, Vol: 28
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• Journal article
  Dong C, Lu S, Deng Z, Cai X, Shen H, Shi G, Ou C, Peng Z, Jiang W, Fu X, Wang C, Jin M, Qiu Z, Wei X, Gu W, Huang K, Li Q, Zhang X, Zhong N, Chung KF, Zhang Qet al., 2025,

  Role for Complement C5 in Eosinophilic Inflammation of Severe Asthma

  , ALLERGY, ISSN: 0105-4538
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  • Citations: 1
• Journal article
  Brown AC, Carroll OR, Mayall JR, Zounemat-Kermani N, Vinzenz SLE, Gomez HM, Mills EF, Kim RY, Donovan C, Baines KJ, Williams EJ, Berthon BS, Wynne K, Scott HA, Pinkerton JW, Guo Y, Hansbro PM, Foster PS, Wark PAB, Dahlen S-E, Adcock IM, Wood LG, Horvat JCet al., 2025,

  Female sex hormones and the oral contraceptive pill modulate asthma severity through GLUT-1

  , MUCOSAL IMMUNOLOGY, Vol: 18, Pages: 656-667, ISSN: 1933-0219
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  • Citations: 1
• Journal article
  Agache I, Adcock IM, Akdis CA, Akdis M, Bentabol-Ramos G, van den Berge M, Boccabella C, Canonica GW, Caruso C, Couto M, Davila I, Drummond D, Fonseca J, Gherasim A, del Giacco S, Jackson DJ, Jutel M, Licari A, Loukides S, Moreira A, Mukherjee M, Ojanguren I, Palomares O, Papi A, de Llano LP, Price OJ, Rukhazde M, Shamji MH, Shaw D, Sanchez-Garcia S, Testera-Montes A, Torres MJ, Eguiluz-Gracia Iet al., 2025,

  The Bronchodilator and Anti-Inflammatory Effect of Long-Acting Muscarinic Antagonists in Asthma: An EAACI Position Paper

  , ALLERGY, Vol: 80, Pages: 1817-1819, ISSN: 0105-4538
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• Journal article
  MacLeod MA, Knott KD, Allinson JP, Finney LJ, Wiseman DJ, Ritchie AI, Braddy-Green A, Barlett-Pestell S, Lopez R, Sun L, Webb P, Dalal P, Rubens M, Davies S, Haskard DO, Devaraj A, Donaldson GC, Khamis RY, Nicol ED, Wedzicha JAet al., 2025,

  Prevalence and Clinical Correlates of Radiologically Detected Coronary Artery Disease in Chronic Obstructive Pulmonary Disease A Cross-Sectional Observational Study

  , AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 211, Pages: 946-956, ISSN: 1073-449X
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  • Citations: 3
• Journal article
  Bloom CI, Lee B, 2025,

  Limitations in Assessing Antidiabetic Medications and Asthma Attacks-Reply

  , JAMA INTERNAL MEDICINE, Vol: 185, Pages: 745-746, ISSN: 2168-6106
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• Journal article
  Gakidi A, Hopkinson NS, Polkey MI, Boutou AKet al., 2025,

  Clinical implications of Pseudomonas aeruginosa colonization in chronic obstructive pulmonary disease patients: is there enough evidence?

  , Chronic Obstructive Pulmonary Diseases, Vol: 12, Pages: 207-209, ISSN: 2372-952X
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• Journal article
  Laiman V, Peng S-W, Choridah L, Heriyanto DS, Yuliani FS, Lee K-Y, Lai C-H, Chang J-H, Lee Y-L, Ho S-C, Wu S-M, Han C-L, Lin C-W, Chung KF, Chuang H-Cet al., 2025,

  ITIH4 attenuates acute lung injury by Fe-containing particulate matter in mice via Hippo pathway in type II alveolar epithelial cells

  , RESPIRATORY RESEARCH, Vol: 26
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• Journal article
  Liu Y-H, Lee Y-L, Han C-L, Lo Y-C, Liao Z-A, Shih Y-S, Lin Y-W, Peng S-W, Lee K-Y, Ho S-C, Wu S-M, Lin C-W, Chung KF, Chang J-H, Chuang H-Cet al., 2025,

  ITIH4 alleviates OVA-induced asthma by regulating lung-gut microbiota

  , MOLECULAR MEDICINE, Vol: 31, ISSN: 1076-1551
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  • Citations: 1
• Journal article
  Makrufardi F, Rusmawatiningtyas D, Murni IK, Arguni E, Lin Y-C, Ho K-F, Chung KF, Lin S-C, Chuang H-Cet al., 2025,

  Seasonal variation of pediatric asthma exacerbations and its association with asthma phenotypes

  , PEDIATRIC RESEARCH, ISSN: 0031-3998
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• Conference paper
  Walsh SL, Sherlock SP, Ostridge K, Ble F, Belvisi MG, Molyneaux PL, Maher TM, Montiero M, Kanavati F, Johnson SR, Saini G, Thillai Met al., 2025,

  Deep Learning-Based Short-Term Disease Progression Evaluation Supersedes Automated Baseline CT Phenotype in Predicting Outcomes in Idiopathic Pulmonary Fibrosis

  , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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• Conference paper
  Johnson E, Cant EG, Bidgood L, Pembridge T, McIntosh E, Galloway R, Shuttleworth M, Hennayake C, Lind H, Viligorska K, Hull R, Headley DADL, Connell D, Liddicoat H, Platt A, Belvisi MG, Ostridge K, Azim A, Richardson H, Long MB, Shoemark A, Chalmers JDet al., 2025,

  Relationships Between Neutrophil Function, Cilia Function, and Microbiome Composition in Bronchiectasis: Interim Results From the Brilliant Study

  , 52nd Critical Care Congress of the Society-of-Critical-Care-Medicine (SCCM), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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• Conference paper
  Craster A, Bussell E, Sherlock SP, Ostridge K, Ble F, Belvisi MG, Johnson SR, Saini G, Maher TM, Thillai M, Molyneaux PL, Walsh SLet al., 2025,

  Deep Learning-based Quantitative CT and Proteomics for Predicting Outcomes in Idiopathic Pulmonary Fibrosis

  , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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• Conference paper
  Diop A, Hughes R, Muellerova H, Rapsomaniki E, Belvisi MG, Faner M, Reddel HK, Weinreich UMet al., 2025,

  Differences in the Characteristics and Outcomes by Sex in Patients With Physician-diagnosed Asthma and/or COPD in the NOVELTY Study

  , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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• Conference paper
  Hughes R, McKellar D, Arad N, Muellerova H, Belvisi MG, Sansone RDO, Reddel HK, Papi Aet al., 2025,

  Coving Index: A Novel, Sensitive Spirometric Marker of Small Airways Obstruction10.1164/ajrccm.2025.211.Abstracts.A2566

  , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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• Conference paper
  Small PM, Rudd M, Galvosas M, Chung KFet al., 2025,

  Evaluating Cough Bouts as a Metric for Cough Severity

  , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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• Conference paper
  Price DB, Dickens A, Henley W, Skinner D, Pinnock H, Van Boven J, Roche N, Kostikas K, Beeh KM, Usmani OS, Clark A, Chalmers JD, Kaplan A, Carter V, Smith U, Burnett-Kirton Z, White S, Davis S, Hannan N, Igwe F, Mastoridis P, Mezzi K, Pfister P, Halpin DMet al., 2025,

  Offering Digital Adherence Support Improves Clinical Outcomes for High-Risk Chronic Obstructive Pulmonary Disease (COPD) Patients With Poor Adherence to Inhaled Therapy

  , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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• Conference paper
  Doe G, Taylor SJC, Edwards G, Topalovic M, El-Emir E, Evans RA, Russell R, Smets E, Van Orshoven K, Sylvester KP, Sunjaya AP, Scott DA, Prevost A, De Vos M, Elmahy A, Hopkinson NS, Kon SS, Patel S, Jarrold I, Kennington E, Spain N, Man WD, Hutchinson Aet al., 2025,

  "Help Humans Make the Right Decisions." Patient Perspectives on Artificial Intelligence (AI) Supporting Clinicians in the Interpretation of Spirometry: A Qualitative Study

  , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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• Journal article
  Valencia-Hernández CA, Yu Z, Gehring U, Koppelman GH, Standl M, Flexeder C, Schikowski T, Kress S, Melén E, Gruzieva O, Lõhmus M, Faner R, Agusti A, Wedzicha JA, Garcia-Aymerich J, Koch S, Nieuwenhuijsen M, Lertxundi A, Esplugues A, Ballester F, Arregi A, Markevych I, Chloe I B, Fuertes Eet al., 2025,

  Residential greenspace and lung function throughout childhood and adolescence in five European birth cohorts. A CADSET initiative

  , Environment International, Vol: 199, ISSN: 0160-4120

  Whether greenspace affects lung function is unclear. We explored associations between the level of greenness or presence of urban green space near the home with lung function measures taken repeatedly during childhood and adolescence in five European birth cohorts.Lung function was measured by spirometry between six and 22 years (2–3 times), and 9,206 participants from BAMSE (Sweden), GINI/LISA South and GINI/LISA North (Germany), PIAMA (The Netherlands) and INMA (Spain) contributed at least one lung function measurement. The mean Normalized Difference Vegetation Index (NDVI) in a 300 m buffer and presence of urban green space within a 300 m buffer (yes/no) were estimated at the home address at the time of each spirometry measurement. Cohort-specific associations were assessed using adjusted linear mixed models and combined in a random-effects meta-analysis.Residential greenness was not associated with forced expiratory volume in one second (FEV1), forced vital capacity (FVC) or FEV1/FVC in the meta-analysis (2.3 ml [-3.2, 7.9], 6.2 ml [-3.4, 15.7] and −0.1 [-0.3, 0.1] per 0.1 increase in NDVI, respectively), nor was having a nearby urban green space (−8.6 ml [–22.3, 5.0], −7.6 ml [-24.7, 9.4] and 0.0 [-0.4, 0.3], respectively). Heterogeneity was low to moderate (I2 = 0 –39 %). Asthma, atopy, air pollution, sex, socioeconomic status and urbanization did not modify the null associations.Using repeated data from five large independent European birth cohorts, we did not find associations between vegetation levels around the home or the presence of an urban green space and lung function levels during childhood and adolescence.

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