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  • Journal article
    Rothen-Rutishauser B, Darquenne C, Cipolla D, Usmani Oet al., 2025,

    History of the International Society of Aerosols in Medicine (ISAM): Celebrating the 25th Congress

    , JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, Vol: 38, Pages: 103-105, ISSN: 1941-2711
  • Conference paper
    Chan R, Lipworth BJ, Berti A, Comberiati P, Dandurand R, Diamant Z, Fowler SJ, Galant S, Kuo C, Menzella F, Lombardi C, Salvi SS, Siddiqui SH, Usmani OS, Cottini Met al., 2025,

    Combined Point-of-Care Assessment Using Oscillometry, Spirometry, and FeNO to Optimally Identify an At-risk Asthma Phenotype

    , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
  • Conference paper
    Kimura H, Kermani NZ, Kimura N, Siddiq MM, Francisco D, Adcock IM, Chung K, Kraft Met al., 2025,

    CC16 Confers Protection Against Influenza a Virus Infection in Human Airway Epithelium

    , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
  • Conference paper
    Raby KL, Gaffney E, Koranteng JB, Dixey P, Adcock IM, Menzies-Gow A, Chung K, Bhavsar PKet al., 2025,

    Blood Eosinophil Gene Expression Phenotype Is Altered in Response to Anti-IL-5 Therapy Mepolizumab

    , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
  • Conference paper
    Begg M, Pyle CJ, Patel N, Edwards MR, Londono-Hayes P, Shaw S, Johnston SLet al., 2025,

    APL-10456; An Adjuvanted Rhinovirus Clinical Vaccine Candidate Which Generates Cross-species Humoral and Th1-polarized Cellular Immunity

    , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
  • Conference paper
    Raby KL, Li H, Dixey P, Koranteng JB, Chung K, Bhavsar PKet al., 2025,

    Mechanisms of Anti-IL5RαTherapy Restoring Nasal Epithelial Cell Barrier Function in Severe Eosinophilic Asthma

    , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
  • Conference paper
    Long MB, Hull RC, Gilmour A, Viligorska K, Richardson H, New BJM, Hennayake C, Galloway R, Johnson E, Mcintosh E, Eke Z, Lind H, Band M, Bandara H, Martin G, Aliberti S, Timothy A, Norwell J, Whitehouse J, Addy CL, Finney L, Mitchelmore P, Caskey SJ, Lord RW, Hill AT, Vendrell M, Polverino E, Marin A, Suarez-Cuartin G, Loebinger MR, Tunney M, Cartwright K, Hughes R, Digiandomenico A, Belvisi MG, Brailsford W, Haworth C, Sibila O, Stobo J, Chalmers JDet al., 2025,

    A Bispecific Monoclonal Antibody Targeting Psl and PcrV for Chronic Pseudomonas Aeruginosa Infection in Patients With Bronchiectasis: Results From a Randomized, Double-Blind Placebo-Controlled Trial (GREAT-2)

    , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
  • Conference paper
    Walsh SL, Kanavati F, Montiero M, Sherlock SP, Ble F, Ostridge K, Belvisi MG, Molyneaux P, Maher TM, Johnson SR, Saini G, Thillai Met al., 2025,

    Deep Learning-Based Quantitative CT and CT Phenotype Classification Independently Predict Mortality in Idiopathic Pulmonary Fibrosis, a Prospective Observational Cohort Study

    , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
  • Journal article
    Finney LJ, Mah J, Duvall M, Wiseman D, Kamal F, Fenwick P, Ritchie AI, Kebadze T, Orton C, Bhavsar P, Allinson JP, Macleod M, Mackay AJ, Baraldi F, Kemp S, Singanayagam A, Johnston SL, Byrne AJ, Levy BD, Wedzicha JAet al., 2025,

    Select Airway Specialized Proresolving Mediators Are Associated with Recovery from Nonviral Chronic Obstructive Pulmonary Disease Exacerbations

    , AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 211, Pages: 803-813, ISSN: 1073-449X
  • Journal article
    Bartlett-Pestell S, Wong T, Wedzicha JA, 2025,

    Exacerbating the Problem: Chronic Obstructive Pulmonary Disease and Atrial Fibrillation

    , AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 211, Pages: 695-697, ISSN: 1073-449X
  • Journal article
    Huang M, Wen J, Lu C, Cai X, Ou C, Deng Z, Huang X, Zhang E, Chung KF, Yan J, Zhong N, Zhang Qet al., 2025,

    Residential greenness, genetic susceptibility, and asthma risk: Mediating roles of air pollution in UK and Chinese populations

    , ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, Vol: 296, ISSN: 0147-6513
  • Journal article
    Dielesen J, Ledwaba-Chapman LJ, Kasetti P, Husain NF, Skinner TC, Pengo MF, Whiteman T, Asimakopoulou K, Merritt S, Jones D, Dickel P, Pulakal S, Ward NR, Pepperell J, Steier J, Sathyapala SAet al., 2025,

    Six early CPAP-usage behavioural patterns determine peak CPAP adherence and permit tailored intervention, in patients with obstructive sleep apnoea

    , THORAX, Vol: 80, Pages: 300-308, ISSN: 0040-6376
  • Journal article
    Zein JG, Zounemat-Kermani N, Adcock IM, 2025,

    Development of an asthma health-care burden score as a measure of severity and predictor of remission in SARP III and U-BIOPRED: results from two major longitudinal asthma cohorts (vol 13, pg 35, 2025)

    , LANCET RESPIRATORY MEDICINE, Vol: 13, Pages: e27-e27, ISSN: 2213-2600
  • Journal article
    Jia N, Jin M, Liu Y, Su N, Sun Y, Tang W, Wang G, Xie H, Xie J, Xie M, Yao X, Zhang H, Chen R, Liu C, Li J, Zhong NS, Chung KF, Wong GWK, OByrne PM, Guo Y, Shao J, Zhao L, Chang C, Zhao H, Hao C, Feng J, Wang Y, Su X, Gao Y, Mei Jet al., 2025,

    The management of type 2 inflammatory respiratory diseases: a Chinese expert consensus [2024]

    , Journal of Thoracic Disease, Vol: 17, Pages: 1807-1831, ISSN: 2072-1439

    Background: Type 2 (T2) inflammatory respiratory diseases encompass a range of conditions characterized by inflammation affecting the airways and lung parenchyma, with their pathogenesis rooted in T2 inflammation. Biological treatments that mitigate T2 inflammation revolutionize the therapeutic landscape for these respiratory diseases. However, there are decision-making difficulties in terms of the target population, timing of initiation, and type selection for biological targeted therapy. Methods: Search strategies were focused on relevant issues related to T2 inflammatory respiratory diseases from PubMed with search date from 2014 to 2024. The quality of evidence and grading recommendations were assessed with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Consensus was achieved through two rounds of anonymous voting with a strong recommendation demanding at least 70% approval from the participants. Results: A total of 370 basic research results and clinical evidence-based medical data were collected and reviewed. The latest research advances, clinical evidence, and expert insights relating to the use of biological treatments aiming at T2 inflammation in respiratory diseases and their co-morbidities were discussed rigorously and iteratively by an expert panel, and a consensus report with recommendations is presented. Conclusions: This consensus outlines the pathogenesis, assessment of T2 inflammation, biological therapies targeted at T2 inflammation, and management strategies for T2 inflammatory respiratory diseases and their comorbidities. It will serve as a valuable guide for clinicians in China, empowering them to diagnose and manage these conditions more effectively.
  • Journal article
    Harvey C, Leedham-Green KE, Koppel C, Maini A, Smith SF, Morrell MJ, Emerson Met al., 2025,

    Improving medical students’ learning strategies, management of workload and wellbeing: a mixed methods case study in undergraduate medical education

    , BMC Medical Education, Vol: 25, ISSN: 1472-6920

    Background:The transition from secondary education to university challenges students’ learning strategies and academic performance, especially in self-directed, problem-based environments like medical school. Passive study methods often fail, while evidence-based strategies like retrieval practice, active learning, and growth mindset foster success. We evaluate a novel academic support programme (Academic Tutoring- (AT)) to enhance study skills, feedback use, and self-directed learning.Methods:We developed and implemented AT for 1st year medical students, informed by the psychology of learning and behaviour change, AT aimed to support the development of self-efficacy and effective learning strategies during the transition into university. The programme involved meeting an Academic Tutor one-to-one once per term, and also as a group once per term. Academic Tutors engaged students in learner-centred conversations on study skills and professional development plus their wellbeing and welfare. A Likert questionnaire was designed to measure students’ responses to the experiences and perceived outcomes of AT. We also measured self-efficacy and mindset. Qualitative data was gathered through open-ended response items. Demographic and socioeconomic data was also gathered.Results:AT positively impacted time-management and learning strategies. ‘Learning from successes and failures’ and ‘thinking how to achieve goals’ were associated with a growth mindset. All outcome measures were associated with self-efficacy. We noted that students from a widening participation (WP) background tended to show higher growth mindset relative to those from a non-WP background (r = -0.223, p = 0.08) and female students reported higher engagement with the programme (r-0.294, p < 0.001). Students reported changes in behaviours and attitudes, and improved wellbeing.Conclusions:Providing medical students with the tools to
  • Journal article
    Oqua AI, Chao K, El Eid L, Casteller L, Baxter BP, Miguéns-Gómez A, Barg S, Jones B, Bernardino de la Serna J, Rouse SL, Tomas Aet al., 2025,

    Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells

    , eLife, Vol: 13, ISSN: 2050-084X

    G protein-coupled receptors (GPCRs) are integral membrane proteins which closely interact with their plasma membrane lipid microenvironment. Cholesterol is a lipid enriched at the plasma membrane with pivotal roles in the control of membrane fluidity and maintenance of membrane microarchitecture, directly impacting on GPCR stability, dynamics, and function. Cholesterol extraction from pancreatic beta cells has previously been shown to disrupt the internalisation, clustering, and cAMP responses of the glucagon-like peptide-1 receptor (GLP-1R), a class B1 GPCR with key roles in the control of blood glucose levels via the potentiation of insulin secretion in beta cells and weight reduction via the modulation of brain appetite control centres. Here, we unveil the detrimental effect of a high cholesterol diet on GLP-1R-dependent glucoregulation in vivo, and the improvement in GLP-1R function that a reduction in cholesterol synthesis using simvastatin exerts in pancreatic islets. We next identify and map sites of cholesterol high occupancy and residence time on active <jats:italic>vs</jats:italic> inactive GLP-1Rs using coarse-grained molecular dynamics (cgMD) simulations, followed by a screen of key residues selected from these sites and detailed analyses of the effects of mutating one of these, Val229, to alanine on GLP-1R-cholesterol interactions, plasma membrane behaviours, clustering, trafficking and signalling in INS-1 832/3 rat pancreatic beta cells and primary mouse islets, unveiling an improved insulin secretion profile for the V229A mutant receptor. This study (1) highlights the role of cholesterol in regulating GLP-1R responses in vivo; (2) provides a detailed map of GLP-1R - cholesterol binding sites in model membranes; (3) validates their functional relevance in beta cells; and (4) highlights their potential as locations for the rational design of novel allosteric modulators with the capacity to fine-tune GLP-1R responses.
  • Journal article
    Makrufardi F, Peng S-W, Chung KF, Chadeau-Hyam M, Lee K-Y, Hsiao T-C, Ho K-F, Rusmawatiningtyas D, Murni IK, Arguni E, Wang Y-H, Ho S-C, Yang F-M, Chuang K-J, Lin S-C, Chuang H-Cet al., 2025,

    Extreme temperatures modulate gene expression in the airway epithelium of the lungs in mice and asthma patients

    , FRONTIERS IN MEDICINE, Vol: 12
  • Journal article
    Siegal EZ, Schoevers JMH, Terstappen J, Delemarre EM, Johnston SL, van Beek LF, Bogaert D, Chiu C, Diavatopoulos DA, Ferreira DM, Gordon SB, Hayden FG, de Jonge MI, Mccall MBB, Mcshane HI, Minassian AM, Openshaw PJM, Pollard AJ, Sattabongkot J, Read RC, Troelstra A, Viveen MC, Wilder-Smith A, van Wijk M, Bont LJ, Mazur NIet al., 2025,

    Risk analysis for outpatient experimental infection as a pathway for affordable RSV vaccine development

    , NPJ VACCINES, Vol: 10
  • Journal article
    Hopkinson N, Polkey M, Price L, McCabe C, Alasmari A, Al Sulayyim A, Alghamdi S, Hudson S, Rickman M, Mitchell J, Ahmetaj-Shala Bet al., 2025,

    Dietary nitrate supplementation enhances exercise capacity in WHO Group 3 pulmonary hypertension: a double-blind, placebo-controlled, randomised crossover study (EDEN-OX2)

    , Thorax, Vol: 80, Pages: 335-338, ISSN: 0040-6376

    Dietary nitrate supplementation, which improves skeletal muscle oxygen utilisation, vascular endothelial function and exercise capacity in people with chronic obstructive pulmonary disease, may benefit other lung conditions. In a double-blind, placebo-controlled, crossover study, in 19 adults with Group 3 pulmonary hypertension who desaturated during exercise, 140 mL of nitrate-rich beetroot juice improved endurance shuttle walk time compared with nitrate-depleted beetroot juice placebo (median (IQR) ESWT NR-BRJ 197 (140–273) s vs PL-BRJ 174 (107–229) s; median difference (MD) (95% CI) 30 (6.19 to 91.07) s, p=0.0281), endothelial function, flow-mediated dilatation (+3.40±5.47% vs −1.33±4.78; MD (95% CI) 4.73 (1.44 to 8.02), p=0.007) and lowered mean arterial blood pressure (−3.9 (−7.4 to −0.4) mm Hg, p=0.028).
  • Journal article
    Haines J, Belvisi MG, Dubuis EC, Dockry RJ, Holt KJ, Hull JH, Yorke J, Fowler SJ, Smith JAet al., 2025,

    Protocol for a double-blind crossover randomised controlled trial to investigate inhalation challenge to assess inducible laryngeal obstruction: CH-ILO

    , ERJ Open Research, Vol: 11, ISSN: 2312-0541

    IntroductionInducible laryngeal obstruction (ILO) remains a poorly understood condition in part due to lack of understanding about the underlying neuronal mechanisms. Many suffer delayed confirmed diagnosis as no standardised assessment exists. Based on previous work, we propose citric acid (CA) is the most appropriate inhalation agent for inducing upper airway reflex responses, with a view to developing an inhalation challenge test for ILO.Methods and analysisThis is a single-centre, double-blind crossover study. The primary objective is to identify if CA inhalation challenge provokes laryngeal obstruction in patients with confirmed ILO. We will recruit 10 participants with ILO, 10 with refractory chronic cough (RCC) and 10 healthy controls. Each participant will undergo two inhalation challenges during laryngoscopy, with ascending concentrations of CA or saline control; they will be randomised sequentially by a computer-generated schedule to determine order of delivery. Follow-up is a telephone consultation. Randomisation and preparation of challenge agents will be by an unblinded study team member not involved in data analysis. Challenge agents will only be unblinded on study completion. Log10 concentration of CA evoking ILO will be compared between patient groups using a one-way ANOVA, comparing participants with ILO and participants with RCC to healthy controls.ConclusionThis will be the first randomised controlled trial to investigate the role of inhalation challenge as an assessment tool to evoke laryngeal obstruction in patients with confirmed ILO. If results prove CA inhalation challenge agent provokes ILO, it will provide new insights into neuronal mechanisms and support development of a standardised diagnostic test.

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