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Journal articleBarnes PJ, 2025,
Senotherapy for chronic lung disease
, PHARMACOLOGICAL REVIEWS, Vol: 77, ISSN: 0031-6997- Cite
- Citations: 2
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Journal articleAdcock IM, Mumby S, Hansel TT, 2025,
Identifying allergic and nonallergic type 2 asthma endotypes: Moving beyond blood eosinophil counts and fractional exhaled nitric oxide
, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 156, Pages: 100-102, ISSN: 0091-6749 -
Journal articleSingh D, Guller P, Reid F, et al., 2025,
A phase 2a trial of the IL-33 monoclonal antibody tozorakimab in patients with COPD: FRONTIER-4
, EUROPEAN RESPIRATORY JOURNAL, Vol: 66, ISSN: 0903-1936- Cite
- Citations: 7
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Journal articleUsmani O, Verbanck S, 2025,
Structure-function-treatment relationships of aerosol deposition in patients with severe asthma
, THORAX, Vol: 80, Pages: 410-411, ISSN: 0040-6376 -
Journal articleDelgado-Ortiz L, Buekers J, Chynkiamis N, et al., 2025,
How do people with COPD walk? A European study on digitally measured real-world gait
, EUROPEAN RESPIRATORY JOURNAL, Vol: 66, ISSN: 0903-1936 -
Journal articleLiu Y-H, Lee Y-L, Han C-L, et al., 2025,
ITIH4 alleviates OVA-induced asthma by regulating lung-gut microbiota (vol 31,204,2025)
, MOLECULAR MEDICINE, Vol: 31, ISSN: 1076-1551 -
Journal articleYang F, McDowell R, Busby J, et al., 2025,
Pre-biologic assessment of adherence in severe asthma and association with biologic continuation: a UK Severe Asthma Registry Study
, BMJ Open Respiratory Research, Vol: 12, ISSN: 2052-4439Background Biologic therapies are approved for uncontrolled severe asthma despite good adherence to inhaled corticosteroids (ICS) and additional controllers. We examined the adherence assessments used across UK Severe Asthma Centres (SACs) and their relationship with biologic continuation and response.Methods UK SACs completed a quantitative survey on adherence assessment practices in 2022. We included all adult patients with severe asthma patients on ICS starting biologic therapy from the UK Severe Asthma Registry, which collects pre-biologic adherence data, including medication possession ratio (MPR), fractional exhaled nitric oxide (FeNO) suppression testing and serum prednisolone levels. Biologic continuation and response were defined as continuation on any biologic and the same biologic after 1 year, respectively. Associations were determined using multivariable logistic regression.Results At 21 SACs, MPR for ICS was assessed at 19 (90%) centres, prednisolone and/or cortisol levels in patients on daily oral corticosteroids at 15 (71%), and FeNO suppression testing at 9 (43%). Of 3307 biologic-initiated patients, 1943 (59%) had MPR for ICS recorded, of which 1802 (93%) demonstrated good adherence (≥75% MPR). Only 110 (9%) and 272 (16%) had FeNO suppression and serum prednisolone results, respectively. Good ICS adherence was associated with 2.65-fold higher odds (95% CI 1.02 to 6.91) of biologic continuation, but not with biologic response (OR 1.37, 95% CI 0.50 to 3.76).Conclusion Good pre-biologic ICS adherence, measured using MPR, is associated with biologic continuation at 1 year. Further research is needed to determine whether baseline adherence predicts biologic response based on clinical and biologic criteria.
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Journal articleZhou X-H, Prothon S, Liathdale E, et al., 2025,
A phase 1 study evaluating the safety, tolerability, and pharmacokinetics of the porcupine inhibitor, AZD5055
, ISCIENCE, Vol: 28 -
Journal articleDong C, Lu S, Deng Z, et al., 2025,
Role for Complement C5 in Eosinophilic Inflammation of Severe Asthma
, ALLERGY, ISSN: 0105-4538- Cite
- Citations: 1
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Journal articleBloom CI, Lee B, 2025,
Limitations in Assessing Antidiabetic Medications and Asthma Attacks-Reply
, JAMA INTERNAL MEDICINE, Vol: 185, Pages: 745-746, ISSN: 2168-6106 -
Journal articleAgache I, Adcock IM, Akdis CA, et al., 2025,
The Bronchodilator and Anti-Inflammatory Effect of Long-Acting Muscarinic Antagonists in Asthma: An EAACI Position Paper
, ALLERGY, Vol: 80, Pages: 1817-1819, ISSN: 0105-4538 -
Journal articleMacLeod MA, Knott KD, Allinson JP, et al., 2025,
Prevalence and Clinical Correlates of Radiologically Detected Coronary Artery Disease in Chronic Obstructive Pulmonary Disease A Cross-Sectional Observational Study
, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 211, Pages: 946-956, ISSN: 1073-449X- Cite
- Citations: 3
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Journal articleBrown AC, Carroll OR, Mayall JR, et al., 2025,
Female sex hormones and the oral contraceptive pill modulate asthma severity through GLUT-1
, MUCOSAL IMMUNOLOGY, Vol: 18, Pages: 656-667, ISSN: 1933-0219- Cite
- Citations: 1
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Journal articleGakidi A, Hopkinson NS, Polkey MI, et al., 2025,
Clinical implications of Pseudomonas aeruginosa colonization in chronic obstructive pulmonary disease patients: is there enough evidence?
, Chronic Obstructive Pulmonary Diseases, Vol: 12, Pages: 207-209, ISSN: 2372-952X -
Journal articleLaiman V, Peng S-W, Choridah L, et al., 2025,
ITIH4 attenuates acute lung injury by Fe-containing particulate matter in mice via Hippo pathway in type II alveolar epithelial cells
, RESPIRATORY RESEARCH, Vol: 26 -
Journal articleLiu Y-H, Lee Y-L, Han C-L, et al., 2025,
ITIH4 alleviates OVA-induced asthma by regulating lung-gut microbiota
, MOLECULAR MEDICINE, Vol: 31, ISSN: 1076-1551- Cite
- Citations: 1
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Journal articleMakrufardi F, Rusmawatiningtyas D, Murni IK, et al., 2025,
Seasonal variation of pediatric asthma exacerbations and its association with asthma phenotypes
, PEDIATRIC RESEARCH, ISSN: 0031-3998 -
Conference paperCraster A, Bussell E, Sherlock SP, et al., 2025,
Deep Learning-based Quantitative CT and Proteomics for Predicting Outcomes in Idiopathic Pulmonary Fibrosis
, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X -
Conference paperDiop A, Hughes R, Muellerova H, et al., 2025,
Differences in the Characteristics and Outcomes by Sex in Patients With Physician-diagnosed Asthma and/or COPD in the NOVELTY Study
, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X -
Conference paperHughes R, McKellar D, Arad N, et al., 2025,
Coving Index: A Novel, Sensitive Spirometric Marker of Small Airways Obstruction10.1164/ajrccm.2025.211.Abstracts.A2566
, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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