In this section
@article{Thomas:2025:10.1002/jcsm.70051,
author = {Thomas, AN and Kalakoutas, A and Yates, M and Yap, J and Sanders, J and Kemp, P and Griffiths, MJD},
doi = {10.1002/jcsm.70051},
journal = {Journal of Cachexia, Sarcopenia and Muscle},
title = {Mitochondrial dysfunction contributes to sustained muscle loss after cardiac surgery: a prospective observational study},
url = {http://dx.doi.org/10.1002/jcsm.70051},
volume = {16},
year = {2025}
}
TY - JOUR
AB - BackgroundAs a major systemic insult, cardiac surgery can lead to significant muscle loss, which increases the time to recovery as well as being correlated with mortality. Highly variable loss of muscle mass (0%–40% rectus femoris cross-sectional area [RFcsa]) and strength in the week after surgery has aided understanding of mechanisms of sarcopenia after acute illness. To include muscle recovery, patients' muscle phenotype beyond the first week after surgery and up to their return as outpatients was studied and correlated with protein and metabolomic markers.MethodsPatients undergoing elective aortic valve surgery were recruited. Muscle mass (RFcsa), strength (handgrip, knee extension and spirometry), body composition (by bioimpedance) and health-related quality of life (generic questionnaire EQ-5D-5L) were determined pre-operatively, 7 days after surgery and at outpatient follow-up. Blood samples were taken on Days 0, 1, 3, 7 and follow-up. The plasma metabolome was determined in 20 patients at Days 0, 3, 7 and follow-up.ResultsOf 31 participants, 20 were male: mean age 68.8 years with a range between 48 and 85 years. Proportionate mean loss of RFcsa between pre-op and Day 7 values was 6.44% [95% CI 4.21 to 8.68, n = 31]; between pre-op and follow-up 9.69% [95% CI 4.92 to 14.96, n = 22]; and between Day 7 and follow-up 3.60% [95% CI −1.30 to 8.48, n = 22]. By contrast to measures of muscle bulk, the strength and functionality assessments (knee extension, handgrip, spirometry and short physical performance battery) decreased in the first week after surgery (pre-op to Day 7) followed by a return to baseline (Day 7 to follow-up). Health-related quality of life (cross-walk index) changed little over the course of the study but correlated positively at follow-up with muscle bulk (RFcsa: r = 0.58 [95% CI 0.19 to 0.81] p = 0.005) and strength of knee extension (r&thinsp
AU - Thomas,AN
AU - Kalakoutas,A
AU - Yates,M
AU - Yap,J
AU - Sanders,J
AU - Kemp,P
AU - Griffiths,MJD
DO - 10.1002/jcsm.70051
PY - 2025///
SN - 2190-5991
TI - Mitochondrial dysfunction contributes to sustained muscle loss after cardiac surgery: a prospective observational study
T2 - Journal of Cachexia, Sarcopenia and Muscle
UR - http://dx.doi.org/10.1002/jcsm.70051
UR - https://doi.org/10.1002/jcsm.70051
VL - 16
ER -