BibTex format
@article{Mueller:2025:10.1080/25310429.2025.2470566,
author = {Mueller, A and Wouters, E and Burney, P and Potts, J and Cardoso, J and Al, Ghobain M and Studnicka, M and Obaseki, D and Elsony, A and Mortimer, K and Mannino, D and Jogi, R and Ahmed, R and Nafees, A and Rodrigues, F and Bárbara, C and Nielsen, R and Gislason, T and Cherkaski, H and El, Rhazi K and Janson, C and Anand, M and Juvekar, S and Dias, H and Franssen, F and Agarwal, D and Hartl, S and Seemungal, T and Paraguas, S and Harrabi, I and Denguezli, M and Rashid, A and Erhabor, G and El, Biaze M and Koul, P and Janssen, D and Amaral, A},
doi = {10.1080/25310429.2025.2470566},
journal = {Pulmonology},
title = {Quality of life associated with breathlessness in the multinational Burden of Obstructive Lung Disease (BOLD) study: a cross-sectional analysis},
url = {http://dx.doi.org/10.1080/25310429.2025.2470566},
volume = {31},
year = {2025}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - IntroductionEvidence of an association between breathlessness and quality of life from population-based studies is limited. We aimed to investigate the association of both physical and mental quality of life with breathlessness across several low-, middle- and high-income countries.MethodsWe analysed data from 19 714 adults (31 sites, 25 countries) from the Burden of Obstructive Lung Disease (BOLD) study. We measured both mental and physical quality of life components using the SF-12 questionnaire, and defined breathlessness as grade ≥2 on the modified Medical Research Council scale. We used multivariable linear regression to assess the association of each quality-of-life component with breathlessness. We pooled site-specific estimates using random-effects meta-analysis.ResultsBoth physical and mental component scores were lower in participants with breathlessness compared to those without. This association was stronger for the physical component (coefficient = −7.59; 95%CI −8.60, −6.58; I2 = 78.5%) than for the mental component (coefficient = −3.50; 95%CI −4.36, −2.63; I2 = 71.4%). The association between physical component and breathlessness was stronger in high-income countries (coefficient = −8.82; 95%CI −10.15, −7.50). Heterogeneity across sites was partly explained by sex and tobacco smoking.ConclusionQuality of life is worse in people with breathlessness, but this association varies widely across the world.
AU - Mueller,A
AU - Wouters,E
AU - Burney,P
AU - Potts,J
AU - Cardoso,J
AU - Al,Ghobain M
AU - Studnicka,M
AU - Obaseki,D
AU - Elsony,A
AU - Mortimer,K
AU - Mannino,D
AU - Jogi,R
AU - Ahmed,R
AU - Nafees,A
AU - Rodrigues,F
AU - Bárbara,C
AU - Nielsen,R
AU - Gislason,T
AU - Cherkaski,H
AU - El,Rhazi K
AU - Janson,C
AU - Anand,M
AU - Juvekar,S
AU - Dias,H
AU - Franssen,F
AU - Agarwal,D
AU - Hartl,S
AU - Seemungal,T
AU - Paraguas,S
AU - Harrabi,I
AU - Denguezli,M
AU - Rashid,A
AU - Erhabor,G
AU - El,Biaze M
AU - Koul,P
AU - Janssen,D
AU - Amaral,A
DO - 10.1080/25310429.2025.2470566
PY - 2025///
SN - 2531-0429
TI - Quality of life associated with breathlessness in the multinational Burden of Obstructive Lung Disease (BOLD) study: a cross-sectional analysis
T2 - Pulmonology
UR - http://dx.doi.org/10.1080/25310429.2025.2470566
UR - https://www.tandfonline.com/doi/full/10.1080/25310429.2025.2470566
VL - 31
ER -
