BibTex format
@article{Adriouch:2025:10.1080/19490976.2025.2599565,
author = {Adriouch, S and Belda, E and Swartz, TD and Forslund, S and Prifti, E and Aron-Wisnewsky, J and Chakaroun, R and Nielsen, T and Poitou, C and Bel-Lassen, P and Rouault, C and Le, Roy T and Andrikopoulos, P and Chechi, K and Puig-Castellvi, F and Dionicio, IC and Froguel, P and Holmes, B and Alili, R and Andreelli, F and Soula, H and Salem, J-E and Falony, G and Vieira-Silva, S and Raes, J and Bork, P and Stumvoll, M and Pedersen, O and Ehrlich, SD and Dumas, M-E and Oppert, J-M and Dao, MC and Zucker, J-D and Clement, K},
doi = {10.1080/19490976.2025.2599565},
journal = {Gut Microbes},
title = {Prominent mediatory role of gut microbiome in the effect of lifestyle on host metabolic phenotypes},
url = {http://dx.doi.org/10.1080/19490976.2025.2599565},
volume = {17},
year = {2025}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Lifestyle factors influence both gut microbiome composition and host metabolism, yet their combined and mediating effects on host phenotypes remain poorly characterized in cardiometabolic populations. In 1,643 participants from the MetaCardis study, we developed a composite lifestyle score (QASD: dietary quality, physical activity, smoking, and diet diversity) that outperformed individual lifestyle variables in explaining microbial gene richness and exhibited a significant impact on the gut microbiome composition. While bidirectional pathways linking the QASD score, host phenotypes, and microbiome composition were assessed, causal inference-based mediation analyses indicated stronger effects when the microbiome was modeled as the mediator variable, particularly in relation to the insulin resistance-associated profile. Microbiome gene richness emerged as a key mediator explaining 27.8% of QASD score’s effect on the insulin resistance marker (HOMA-IR), while no significant mediation was observed on BMI. Extended mediation analyses on microbial species and serum metabolomics deconfounded for drug use and clinical profiles identified 47 mediations where microbial taxa mediated more than 20% of the effect of the QASD score on serum metabolites associated with insulin resistance. Notably, several Faecalibacterium lineages enriched in individuals with high QASD score played a significant mediatory role in increasing the serum biomarkers of microbiome diversity (as cinnamoylglycine or 3-phenylpropionate). Conversely, elevated levels of secondary bile acids in individuals with low QASD scores were strongly mediated by high levels of Clostridium bolteae. These findings highlight distinct and clinically relevant microbiome pathways linking lifestyle behaviors to cardiometabolic risks.
AU - Adriouch,S
AU - Belda,E
AU - Swartz,TD
AU - Forslund,S
AU - Prifti,E
AU - Aron-Wisnewsky,J
AU - Chakaroun,R
AU - Nielsen,T
AU - Poitou,C
AU - Bel-Lassen,P
AU - Rouault,C
AU - Le,Roy T
AU - Andrikopoulos,P
AU - Chechi,K
AU - Puig-Castellvi,F
AU - Dionicio,IC
AU - Froguel,P
AU - Holmes,B
AU - Alili,R
AU - Andreelli,F
AU - Soula,H
AU - Salem,J-E
AU - Falony,G
AU - Vieira-Silva,S
AU - Raes,J
AU - Bork,P
AU - Stumvoll,M
AU - Pedersen,O
AU - Ehrlich,SD
AU - Dumas,M-E
AU - Oppert,J-M
AU - Dao,MC
AU - Zucker,J-D
AU - Clement,K
DO - 10.1080/19490976.2025.2599565
PY - 2025///
SN - 1949-0976
TI - Prominent mediatory role of gut microbiome in the effect of lifestyle on host metabolic phenotypes
T2 - Gut Microbes
UR - http://dx.doi.org/10.1080/19490976.2025.2599565
UR - https://www.tandfonline.com/doi/full/10.1080/19490976.2025.2599565
VL - 17
ER -
