BibTex format
@article{Chechi:2026:10.1038/s41467-026-69405-0,
author = {Chechi, K and Chakaroun, R and Myridakis, A and Forslund-Startceva, SK and Fromentin, S and Nielsen, T and Aron-Wisneswky, J and Belda, E and Prifti, E and Lassen, PB and Falony, G and Vieira-Silva, S and Chilloux, J and Sonomura, K and Hoyles, L and Martinez-Gili, L and Pallotti, F and Andrikopoulos, P and Puig-Castellví, F and Tapia, RP and Castro-Dionicio, I and Roume, H and Pons, N and Le, Chatelier E and Quinquis, B and Galleron, N and Berland, M and Olanipekun, MT and Jia, M and Manolias, A and Holmes, B and Adriouch, S and Blüher, M and Coelho, LP and Da, Silva K and Galan, P and Ji, B and Neves, AL and Rouault, C and Salem, J-E and Tremaroli, V and Hansen, TH and Søndertoft, NB and Lewinter, C and Pedersen, HK and MetaCardis, Consortium and Mark, PD and Goetze, JP and Køber, L and Vestergaard, H and Hansen, T and Zucker, J-D and Sato, T-A and Hercberg, S and Bäckhed, F and Letunic, I and Oppert, J-M and Nielsen, J and Raes, J and Tzoulaki, I and Dehghan, A and Zuber, V and Bouz},
doi = {10.1038/s41467-026-69405-0},
journal = {Nat Commun},
title = {A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases.},
url = {http://dx.doi.org/10.1038/s41467-026-69405-0},
year = {2026}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Cardiovascular diseases (CVD) remain a major global health challenge. Early markers of disease initiation and progression are urgently needed. We, and others, have previously shown changes in the gut microbiome in association with metabolic and CVD. Here, we demonstrate that gut microbiome-related changes can be detected in association with subclinical variations in heart and kidney function. Markers related to gut microbial metabolism of aromatic amino acids, phenylalanine and tyrosine, associate with circulating pro-atrial natriuretic peptide and estimated glomerular filtration rate in a metabolically healthy European population. Observational and genetic evidence further identify microbiome-related metabolites as mediators of this gut microbiome-kidney axis, with their baseline levels associating with incident CVD in an external Canadian population. Altogether, our work suggests that the gut microbiome interacts with the cardiorenal axis and participates in an interorgan crosstalk affecting host physiology and risk of CVD.
AU - Chechi,K
AU - Chakaroun,R
AU - Myridakis,A
AU - Forslund-Startceva,SK
AU - Fromentin,S
AU - Nielsen,T
AU - Aron-Wisneswky,J
AU - Belda,E
AU - Prifti,E
AU - Lassen,PB
AU - Falony,G
AU - Vieira-Silva,S
AU - Chilloux,J
AU - Sonomura,K
AU - Hoyles,L
AU - Martinez-Gili,L
AU - Pallotti,F
AU - Andrikopoulos,P
AU - Puig-Castellví,F
AU - Tapia,RP
AU - Castro-Dionicio,I
AU - Roume,H
AU - Pons,N
AU - Le,Chatelier E
AU - Quinquis,B
AU - Galleron,N
AU - Berland,M
AU - Olanipekun,MT
AU - Jia,M
AU - Manolias,A
AU - Holmes,B
AU - Adriouch,S
AU - Blüher,M
AU - Coelho,LP
AU - Da,Silva K
AU - Galan,P
AU - Ji,B
AU - Neves,AL
AU - Rouault,C
AU - Salem,J-E
AU - Tremaroli,V
AU - Hansen,TH
AU - Søndertoft,NB
AU - Lewinter,C
AU - Pedersen,HK
AU - MetaCardis,Consortium
AU - Mark,PD
AU - Goetze,JP
AU - Køber,L
AU - Vestergaard,H
AU - Hansen,T
AU - Zucker,J-D
AU - Sato,T-A
AU - Hercberg,S
AU - Bäckhed,F
AU - Letunic,I
AU - Oppert,J-M
AU - Nielsen,J
AU - Raes,J
AU - Tzoulaki,I
AU - Dehghan,A
AU - Zuber,V
AU - Bouzigon,E
AU - Lathrop,M
AU - Raina,P
AU - Froguel,P
AU - Matsuda,F
AU - Demenais,F
AU - Gauguier,D
AU - Stumvoll,M
AU - Bork,P
AU - Pedersen,O
AU - Ehrlich,SD
AU - Clément,K
AU - Dumas,M-E
DO - 10.1038/s41467-026-69405-0
PY - 2026///
TI - A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases.
T2 - Nat Commun
UR - http://dx.doi.org/10.1038/s41467-026-69405-0
UR - https://www.ncbi.nlm.nih.gov/pubmed/41786749
ER -
