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@article{Siddiqui:2026:10.1016/j.jaip.2025.10.051,
author = {Siddiqui, SH and Wilson-Morkeh, H and Monti, S and Hellmich, B},
doi = {10.1016/j.jaip.2025.10.051},
journal = {J Allergy Clin Immunol Pract},
pages = {599--610},
title = {Early Diagnosis and Treatment in Patients With Eosinophilic Granulomatosis With Polyangiitis.},
url = {http://dx.doi.org/10.1016/j.jaip.2025.10.051},
volume = {14},
year = {2026}
}
TY - JOUR
AB - Eosinophilic granulomatosis with polyangiitis (EGPA), originally termed Churg-Strauss syndrome, represents the rarest form of antineutrophil cytoplasmic antibody-associated vasculitis. It is characterized by the presence of asthma, rhinosinusitis with or without nasal polyps, eosinophilic inflammation of the blood, and tissues and necrotizing vasculitis of small to medium-sized blood vessels. Owing to its rare, multisystemic nature with diverse symptom presentation, diagnosis is complex, requiring a multidisciplinary approach and a careful array of diagnostic and clinical assessments. Conventional therapy is composed of the use of oral glucocorticoids, which are associated with long-term adverse effects, and other immunomodulatory drugs. However, earlier diagnosis and prompt tailored treatment can improve clinical outcomes and reduce drug-related toxicity. The initiation of biologic therapies, such as those blocking IL-5 or its receptor, which have recently been approved for the treatment of non-severe relapsing EGPA, has emerged as a paradigm shift in management. An illustrative case is used to present a comprehensive representation of the diagnosis, pathophysiology, and management of EGPA.
AU - Siddiqui,SH
AU - Wilson-Morkeh,H
AU - Monti,S
AU - Hellmich,B
DO - 10.1016/j.jaip.2025.10.051
EP - 610
PY - 2026///
SP - 599
TI - Early Diagnosis and Treatment in Patients With Eosinophilic Granulomatosis With Polyangiitis.
T2 - J Allergy Clin Immunol Pract
UR - http://dx.doi.org/10.1016/j.jaip.2025.10.051
UR - https://www.ncbi.nlm.nih.gov/pubmed/41285201
VL - 14
ER -
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