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@article{Course:2026:10.1016/S2213-2600(25)00372-8,
author = {Course, CW and Bush, A and Kotecha, S},
doi = {10.1016/S2213-2600(25)00372-8},
journal = {Lancet Respir Med},
pages = {60--71},
title = {Looking beyond bronchopulmonary dysplasia: prematurity-associated lung disease and its phenotypes.},
url = {http://dx.doi.org/10.1016/S2213-2600(25)00372-8},
volume = {14},
year = {2026}
}
TY - JOUR
AB - Preterm birth is increasingly recognised as a determinant of chronic respiratory disease across the life course. In this Series on prematurity-associated lung disease (PLD), we introduce the concept of PLD as a unifying framework for the diverse pulmonary consequences of preterm birth. Historically, most attention has focused on extremely preterm infants (<28 weeks of gestation) who develop bronchopulmonary dysplasia (BPD), yet not all infants with BPD have long-term morbidity. Conversely, those born very (28-31 weeks), moderate (32-33 weeks), or late (34-36 weeks) preterm also have increased risk for developing lung disease. Multiple factors beyond BPD-including gestational age and intrauterine growth restriction-contribute to PLD development. Recently described PLD phenotypes include prematurity-associated obstructive lung disease, prematurity-associated preserved ratio impaired spirometry, and prematurity-associated dysanapsis. Each phenotype reflects distinct early-life exposures and mechanisms, with differing implications for prognosis. Defining these phenotypes provides a foundation for personalised monitoring and targeted therapeutic strategies.
AU - Course,CW
AU - Bush,A
AU - Kotecha,S
DO - 10.1016/S2213-2600(25)00372-8
EP - 71
PY - 2026///
SP - 60
TI - Looking beyond bronchopulmonary dysplasia: prematurity-associated lung disease and its phenotypes.
T2 - Lancet Respir Med
UR - http://dx.doi.org/10.1016/S2213-2600(25)00372-8
UR - https://www.ncbi.nlm.nih.gov/pubmed/41319663
VL - 14
ER -
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