In this section
@article{Cucco:2025,
author = {Cucco, A and Simpson, A and Murray, C and Roberts, GC and Holloway, JW and Arshad, SH and Custovic, A and Fontanella, S},
journal = {Scientific Reports},
title = {Clustering lung function and symptom profiles for asthma risk stratification},
year = {2025}
}
TY - JOUR
AB - Asthma is a heterogeneous condition often studied through wheeze alone, yet the interplay between lung function and reported symptoms remains underexplored. To capture this heterogeneity, we applied Bayesian Profile Regression to data from school-age children in two prospective birth cohorts, integrating airway hyperresponsiveness, lung function, bronchodilator reversibility, allergic sensitisation, reported symptoms, and physician diagnosis. In the Manchester Allergy and Asthma Study (discovery cohort), five reproducible clusters were identified: HA-LLF (high asthma-low lung function), HA-NLF (high asthma-near-normal lung function), LA-LLF (low asthma-low lung function), LA-NLF (low asthma-normal lung function), and INT-SYM (intermediate asthma with prominent symptoms). The HA-LLF and HA-NLF clusters had very high asthma prevalence (80–100%), but differed markedly in lung function, airway responsiveness, bronchodilator reversibility, sensitisation, and symptom burden. The LA-HLF and LA-NLF clusters with low asthma prevalence (<5%) displayed contrasting lung function profiles, while INT-SYM (~50% asthma prevalence) was largely defined by prominent symptoms such as chest tightness and shortness of breath. These subtypes were replicated in an independent cohort, Isle of Wight. Our findings demonstrate that integrating physiological, immunological, and symptom-based measures yields clinically meaningful asthma subtypes beyond wheeze-based definitions and may support more precise disease classification.
AU - Cucco,A
AU - Simpson,A
AU - Murray,C
AU - Roberts,GC
AU - Holloway,JW
AU - Arshad,SH
AU - Custovic,A
AU - Fontanella,S
PY - 2025///
SN - 2045-2322
TI - Clustering lung function and symptom profiles for asthma risk stratification
T2 - Scientific Reports
ER -
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