In this section
@article{Nguyen:2024:10.1038/s41577-024-01029-1,
author = {Nguyen, THO and Rowntree, LC and Chua, BY and Thwaites, RS and Kedzierska, K},
doi = {10.1038/s41577-024-01029-1},
journal = {Nature Reviews Immunology},
pages = {720--735},
title = {Defining the balance between optimal immunity and immunopathology in influenza virus infection},
url = {http://dx.doi.org/10.1038/s41577-024-01029-1},
volume = {24},
year = {2024}
}
TY - JOUR
AB - Influenza A viruses remain a global threat to human health, with continued pandemic potential. In this Review, we discuss our current understanding of the optimal immune responses that drive recovery from influenza virus infection, highlighting the fine balance between protective immune mechanisms and detrimental immunopathology. We describe the contribution of innate and adaptive immune cells, inflammatory modulators and antibodies to influenza virus-specific immunity, inflammation and immunopathology. We highlight recent human influenza virus challenge studies that advance our understanding of susceptibility to influenza and determinants of symptomatic disease. We also describe studies of influenza virus-specific immunity in high-risk groups following infection and vaccination that inform the design of future vaccines to promote optimal antiviral immunity, particularly in vulnerable populations. Finally, we draw on lessons from the COVID-19 pandemic to refocus our attention to the ever-changing, highly mutable influenza A virus, predicted to cause future global pandemics.
AU - Nguyen,THO
AU - Rowntree,LC
AU - Chua,BY
AU - Thwaites,RS
AU - Kedzierska,K
DO - 10.1038/s41577-024-01029-1
EP - 735
PY - 2024///
SN - 1474-1733
SP - 720
TI - Defining the balance between optimal immunity and immunopathology in influenza virus infection
T2 - Nature Reviews Immunology
UR - http://dx.doi.org/10.1038/s41577-024-01029-1
UR - https://www.ncbi.nlm.nih.gov/pubmed/38698083
UR - https://www.nature.com/articles/s41577-024-01029-1
VL - 24
ER -
