BibTex format
@article{Oner:2024:10.3389/fimmu.2024.1448578,
author = {Oner, D and Vernhes, C and Balla-Jhagjhoorsingh, S and Moureau, A and Crabbe, M and Salaun, B and Bastian, AR and Thys, K and De, Smedt J and Ooft, SN and Korsten, K and Adriaenssens, N and Coenen, S and Butler, CC and Verheij, TJM and Drysdale, SB and Wildenbeest, JG and Pollard, AJ and Openshaw, PJM and Bont, L and Aerssens, J},
doi = {10.3389/fimmu.2024.1448578},
journal = {Frontiers in Immunology},
title = {Serum and mucosal antibody-mediated protection and identification of asymptomatic respiratory syncytial virus infection in community-dwelling older adults in Europe},
url = {http://dx.doi.org/10.3389/fimmu.2024.1448578},
volume = {15},
year = {2024}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Introduction: Respiratory syncytial virus (RSV) causes acute respiratory tract infection (ARTI) and reinfects adults throughout life, posing a risk for hospitalization in older adults (>60 years) with frailty and comorbidities.Methods: To investigate serum and mucosal antibodies for protection against RSV infections, baseline serum samples were compared for RSV-pre- and -post-fusion (F) binding, and RSV-A2 neutralizing IgG antibodies between symptomatic RSV-ARTI (N = 30), non-RSV (RSV negative) ARTI (N = 386), and no ARTI (N = 338). Mucosal RSV-pre-F IgA and IgG levels, as well as serum RSV-G IgG antibodies, were analyzed to determine their association with protection from symptomatic RSV-ARTI in a subset study.Results: Using a receiver operating characteristic (ROC) analysis, we established thresholds of 1.4- to 1.6-fold change (FC) for RSV-pre-F and -post-F, and RSV-A2 neutralizing IgG antibodies, respectively, enabling the identification of asymptomatic RSV cases with high sensitivity and specificity (>80% and >90%, respectively). As a result, serum RSV-pre-F, RSV-G IgG, and mucosal pre-F binding IgA antibodies showed correlations with protection against symptomatic RSV infection. RSV-pre-F IgG antibodies were correlated with protection from RSV infections irrespective of the symptoms.Discussion: This study provides insights into antibody-mediated protection for symptomatic RSV infection in a community-dwelling older-adult population and establishes a threshold to identify asymptomatic RSV infection using a data-driven approach.
AU - Oner,D
AU - Vernhes,C
AU - Balla-Jhagjhoorsingh,S
AU - Moureau,A
AU - Crabbe,M
AU - Salaun,B
AU - Bastian,AR
AU - Thys,K
AU - De,Smedt J
AU - Ooft,SN
AU - Korsten,K
AU - Adriaenssens,N
AU - Coenen,S
AU - Butler,CC
AU - Verheij,TJM
AU - Drysdale,SB
AU - Wildenbeest,JG
AU - Pollard,AJ
AU - Openshaw,PJM
AU - Bont,L
AU - Aerssens,J
DO - 10.3389/fimmu.2024.1448578
PY - 2024///
SN - 1664-3224
TI - Serum and mucosal antibody-mediated protection and identification of asymptomatic respiratory syncytial virus infection in community-dwelling older adults in Europe
T2 - Frontiers in Immunology
UR - http://dx.doi.org/10.3389/fimmu.2024.1448578
UR - https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1448578/full
VL - 15
ER -
