BibTex format
@article{Chen:2025:10.1038/s41467-025-59370-5,
author = {Chen, J-L and Wang, B and Lu, Y and Antoun, E and Bird, O and Drennan, PG and Yin, Z and Liu, G and Yao, X and Pidoux, M and Bates, A and Jayathilaka, D and Wang, J and Angus, B and Beer, S and Espinosa, A and Baillie, JK and Semple, MG and Openshaw, PJM and Alex, B and Andrikopoulos, P and Bach, B and Barclay, WS and Bogaert, D and Chand, M and Chechi, K and Cooke, GS and da, Silva Filipe A and de, Silva T and Docherty, AB and dos, Santos Correia G and Dumas, M-E and Dunning, J and Fletcher, T and Green, CA and Greenhalf, W and Griffin, JL and Gupta, RK and Harrison, EM and Ho, AYW and Holden, K and Horby, PW and Ijaz, S and Khoo, S and Klenerman, P and Law, A and Lewis, MR and Liggi, S and Lim, WS and Maslen, L and Merson, L and Meynert, AM and Moore, SC and Noursadeghi, M and Olanipekun, M and Osagie, A and Palmarini, M and Palmieri, C and Paxton, WA and Pollakis, G and Price, N and Rambaut, A and Robertson, DL and Russell, CD and Sancho-Shimizu, V and Sands, CJ and Scott, JT and Si},
doi = {10.1038/s41467-025-59370-5},
journal = {Nature Communications},
title = {T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination},
url = {http://dx.doi.org/10.1038/s41467-025-59370-5},
volume = {16},
year = {2025}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - In 2022, a global mpox outbreak occurred, and remains a concern today. The T cell memory response to MPXV (monkeypox virus) infection has not been fully investigated. In this study, we evaluate this response in convalescent and MVA-BN (Modified Vaccinia Ankara - Bavarian Nordic) vaccinated individuals using VACV-infected cells. Strong CD8+ and CD4+ T cell responses are observed, and T cell responses are biased towards viral early expressed proteins. We identify seven immunodominant HLA-A02:01 restricted MPXV-specific epitopes and focus our detailed phenotypic and scRNAseq analysis on the immunodominant HLA-A02:01-G5R18-26-specific CD8+ T cell response. While tetramer+CD8+ T cells share similar differentiation and activation phenotypes, T cells from convalescent individuals show greater cytotoxicity, migratory potential to site of infection and TCR clonal expansion. Our data suggest that effective functional profiles of MPXV-specific memory T cells induced by Mpox infection may have an implication on the long-term protective responses to future infection.
AU - Chen,J-L
AU - Wang,B
AU - Lu,Y
AU - Antoun,E
AU - Bird,O
AU - Drennan,PG
AU - Yin,Z
AU - Liu,G
AU - Yao,X
AU - Pidoux,M
AU - Bates,A
AU - Jayathilaka,D
AU - Wang,J
AU - Angus,B
AU - Beer,S
AU - Espinosa,A
AU - Baillie,JK
AU - Semple,MG
AU - Openshaw,PJM
AU - Alex,B
AU - Andrikopoulos,P
AU - Bach,B
AU - Barclay,WS
AU - Bogaert,D
AU - Chand,M
AU - Chechi,K
AU - Cooke,GS
AU - da,Silva Filipe A
AU - de,Silva T
AU - Docherty,AB
AU - dos,Santos Correia G
AU - Dumas,M-E
AU - Dunning,J
AU - Fletcher,T
AU - Green,CA
AU - Greenhalf,W
AU - Griffin,JL
AU - Gupta,RK
AU - Harrison,EM
AU - Ho,AYW
AU - Holden,K
AU - Horby,PW
AU - Ijaz,S
AU - Khoo,S
AU - Klenerman,P
AU - Law,A
AU - Lewis,MR
AU - Liggi,S
AU - Lim,WS
AU - Maslen,L
AU - Merson,L
AU - Meynert,AM
AU - Moore,SC
AU - Noursadeghi,M
AU - Olanipekun,M
AU - Osagie,A
AU - Palmarini,M
AU - Palmieri,C
AU - Paxton,WA
AU - Pollakis,G
AU - Price,N
AU - Rambaut,A
AU - Robertson,DL
AU - Russell,CD
AU - Sancho-Shimizu,V
AU - Sands,CJ
AU - Scott,JT
AU - Sigfrid,L
AU - Solomon,T
AU - Sriskandan,S
AU - Stuart,D
AU - Summers,C
AU - Swann,OV
AU - Takats,Z
AU - Takis,P
AU - Tedder,RS
AU - Thompson,AAR
AU - Thomson,EC
AU - Thwaites,RS
AU - Turtle,LCW
AU - Zambon,M
AU - Drake,TM
AU - Fairfield,CJ
AU - Knight,SR
AU - Mclean,KA
AU - Murphy,D
AU - Norman,L
AU - Pius,R
AU - Shaw,CA
AU - Connor,M
AU - Dalton,J
AU - Gamble,C
AU - Girvan,M
AU - Halpin,S
AU - Harrison,J
AU - Jackson,C
AU - Lee,J
AU - Marsh,L
AU - Plotkin,D
AU - Roberts,S
AU - Saviciute,E
AU - Clohisey,S
AU - Hendry,R
AU - Knight,S
AU - Leeming,G
AU - Norris,L
AU - Scott-Brown,J
AU - Tait,S
AU - Wham,M
AU - Carson,G
AU - Grammatikopoulos,T
AU - McDonald,SE
AU - Shaw,V
AU - Keating,S
AU - Donegan,C
AU - Spencer,RG
AU - Donohue,C
AU - Griffiths,F
AU - Hardwick,H
AU - Oosthuyzen,W
AU - Rostron,T
AU - Waugh,C
AU - Sopp,P
AU - Knight,JC
AU - Fullerton,JN
AU - Coles,M
AU - Smith,GL
AU - Mentzer,AJ
AU - Peng,Y
AU - Dong,T
DO - 10.1038/s41467-025-59370-5
PY - 2025///
SN - 2041-1723
TI - T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination
T2 - Nature Communications
UR - http://dx.doi.org/10.1038/s41467-025-59370-5
UR - https://doi.org/10.1038/s41467-025-59370-5
VL - 16
ER -
