In this section
@article{Guan:2025:10.1002/eji.70043,
author = {Guan, S and Ogger, P and Farias, A and Garcia, Martin M and Nakawesi, J and Bedard, O and Baker, C and Rosenthal, N and Johansson, C},
doi = {10.1002/eji.70043},
journal = {European Journal of Immunology},
title = {Sustained lung inflammation post SARS-CoV-2 infection in mice is associated with increased pulmonary T cells},
url = {http://dx.doi.org/10.1002/eji.70043},
volume = {55},
year = {2025}
}
TY - JOUR
AB - Many SARS-CoV-2 patients experience chronic pulmonary symptoms and long-term inflammation despite viral clearance. While these clinical manifestations have been linked to the dysregulation of the adaptive immune response, the underlying immunopathology remains poorly understood due to a lack of suitable animal models. To investigate long-term pulmonary consequences of SARS-CoV-2 infection, we used a genetic cross of 129 mice and C57BL/6 (B6)-K18-hACE2 transgene mice, a model previously shown to survive infection. 129xB6-K18-hACE2 mice or littermate controls were infected with a low dose (5 × 102 PFU) of ancestral SARS-CoV-2. Complete viral clearance and full recovery from weight loss occurred by day 8 post-infection. However, prolonged inflammation in the lung and airways persisted up to day 28 post-infection and was associated with the presence of CD4+ and CD8+ T cells, particularly CD8+ effector T cells. This model may therefore prove valuable for further understanding of drivers of long-term lung inflammation and for testing therapeutic strategies and clinically relevant interventions that can target long-term pulmonary inflammation following SARS-CoV-2 infection.
AU - Guan,S
AU - Ogger,P
AU - Farias,A
AU - Garcia,Martin M
AU - Nakawesi,J
AU - Bedard,O
AU - Baker,C
AU - Rosenthal,N
AU - Johansson,C
DO - 10.1002/eji.70043
PY - 2025///
SN - 0014-2980
TI - Sustained lung inflammation post SARS-CoV-2 infection in mice is associated with increased pulmonary T cells
T2 - European Journal of Immunology
UR - http://dx.doi.org/10.1002/eji.70043
UR - https://onlinelibrary.wiley.com/doi/10.1002/eji.70043
VL - 55
ER -
