Research Associate

Job summary

Two positions have become available in the laboratory of Professor Speck at Imperial College London (http://www.specklab.com/) to work on exciting DNA replication or chromatin projects employing biochemical & structural or genomic & proteomic approaches. Biochemistry and Structural Biology Biochemistry and structural biology have the potential to reveal highly complex molecular mechanisms. In particular in vitro reconstitution and...

Job listing information

  • Reference MED01698
  • Date posted 27 January 2020
  • Closing date 5 March 2020

Job description

Job summary

Two positions have become available in the laboratory of Professor Speck at Imperial College London (http://www.specklab.com/) to work on exciting DNA replication or chromatin projects employing biochemical & structural or genomic & proteomic approaches.

Biochemistry and Structural Biology

Biochemistry and structural biology have the potential to reveal highly complex molecular mechanisms. In particular in vitro reconstitution and cryo-electron microscopy are ideally suited to investigate large protein assemblies. The successful applicant will work either on:

  1.  A project focussed on DNA replication discovering novel replication mechanisms 
  2. A project focussed on chromatin researching how epigenetics affect chromatin structure.    

Genomics and Proteomics

Advances in genomics and proteomics have made it possible to marry up genomic with proteomic and structural data. Crucially, now it is possible to obtain information on protein complex location and size at a base pair resolution in a genome wide manner generating for the first-time structural data in cells. The successful applicant will:

  1. Use genomic and synthetic biology approaches to address novel mechanism in initiation of DNA replication and DNA repair
  2. Develop new genomic methods to elucidate nucleosome/chromatin structure in order to understand gene regulation in health and disease.

The group consists of 11 researchers, including 6 postdocs, 3 students and 2 technicians. The successful candidates will enjoy intensive interactions with group members specialised in cryo-EM, biochemistry and genomic approaches generating a collaborative and highly productive atmosphere. We are excellently equipped for biochemistry (2 AKTA’s, 4 temperature controlled shakers, 2 freezer mills, constant system french press, Biacore T100), structural EM work (cryo-EM facility with 200kV FEG cryo-EM, Vitrobot IV, GPU- and data storage-cluster and direct access to a Titan Krios with K3 detector as founding member of the LonCEN consortium) and genomics/proteomics (direct access to excellent local sequencing, genomics and proteomics facilities and bioinformatics team).

Duties and responsibilities

By joining the group, the candidates will not only participate in high profile research projects but will also be directly mentored by Professor Speck in grant writing, networking and publishing. Indeed, the scientific framework and the support by Prof. Speck means that the candidates are well placed for a successful transition into independence.

 

 

Essential requirements

You will have a  PhD in biochemistry, genetics, structural biology or neighbouring disciplines, a strong publication record and expertise in method development/trouble shooting. Background in the areas of nucleic acid-protein interactions, chromatin biology, molecular machines, or the broader area of genome stability would be of advantage, but is not necessary.

Further information

The roles are full time and fixed term for 3 years and the latest expected start date is spring 2020.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the Salary range £35,477–£38,566 per annum.

For informal inquiries or questions please contact Professor Christian Speck directly (chris.speck@imperial.ac.uk).

For technical issues when applying online please email recruitment@imperial.ac.uk.

Committed to equality and valuing diversity, we are an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

All Imperial employees are expected to follow the 7 principles of Imperial Expectations: 

  • Champion a positive approach to change and opportunity
  • Communicate regularly and effectively within, and across, teams
  • Consider the thoughts and expectations of others
  • Deliver positive outcomes
  • Encourage inclusive participation and eliminate discrimination
  • Develop and grow skills and expertise
  • Work in a planned and managed way 

In addition to the above, employees are required to observe and comply with all College policies and regulations.

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.