Research Associate or Fellow
We are seeking a Research Associate or Fellow to work on antimicrobial resistance and genomic epidemiology of the major mould pathogen A. fumigatus. The post will be based in the MRC Centre for Global Infectious Disease Analysis (GIDA) within the School of Public Health at Imperial College London. The position is funded by a Wellcome Trust funded 4-year Collaborative Award, led by Prof Matthew Fisher, and will investigate the escalating...
Job listing information
- Reference MED01859
- Date posted 3 June 2020
- Closing date 5 July 2020
We are seeking a Research Associate or Fellow to work on antimicrobial resistance and genomic epidemiology of the major mould pathogen A. fumigatus. The post will be based in the MRC Centre for Global Infectious Disease Analysis (GIDA) within the School of Public Health at Imperial College London.
The position is funded by a Wellcome Trust funded 4-year Collaborative Award, led by Prof Matthew Fisher, and will investigate the escalating incidence of drug-resistant Aspergillus fumigatus coinfections in patients with pulmonary conditions such as cystic fibrosis, influenza and COVID-19.
The understanding we will achieve by this research will be critical for making informed decisions on current clinical and agricultural practice, as well as highlighting the most beneficial novel antifungal agents amongst those in current development (see Fisher et al. Worldwide emergence of resistance to antifungal drugs challenges human health and food security Science 2018).
Duties and responsibilities
The overarching aim of the project is to understand and quantify the risk that presents to public health within two countries, the UK and the Netherlands, where large and well characterised at-risk patient populations are showing an increasing incidence of aspergillosis that is resistant to the widely-used class of azole antifungal drugs. Our research will address the following research questions:
- What are the frequencies of environmentally-acquired and in-host evolved azole-resistant infections and what are the genetic backgrounds upon which they occur?
- Does azole-resistance combine with specific genetic backgrounds to heighten A. fumigatus fitness and virulence?
- Are there genetic barriers to the spread of the emerging spectrum of azole-resistant mutations?
- How does the emergence of azole-resistance impact the efficacy of new incoming antifungal drugs?
You will have a PhD or equivalent in infectious disease epidemiology, bioinformatics, ecology, biostatistics or an alternative highly quantitative discipline and the appropriate technical skills/ experience required to perform all the required technical tasks for genetics/genomics, disease epidemiology, experimental design, bioinformatics (e.g. R, Python, Perl etc).
This post is full time and fixed term for 12 months in the first instance and will be based at the St Mary’s Campus, Paddington. Imperial College is supportive of flexible working. The College is happy to discuss the possibility of implementing such arrangements for this post, with suitably qualified people, subject to operational requirements.
Should you have any queries please contact Prof Matthew Fisher via firstname.lastname@example.org.
For technical issues when applying online please email email@example.com.
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Imperial is a Disability Confident leader
Imperial is working in partnership with GIRES to promote respect and provide equal treatment for trans people