Post-doctoral Research Associate

Job summary

We are seeking a highly motivated postdoctoral scientist to join a collaborative team of research scientists interested in vascular biology. This British Heart Foundation-funded research project, led by Dr Graeme Birdsey at the National Heart and Lung Institute, will investigate the role of the transcription factor ERG in regulating lymphatic endothelial cell gene expression and lymphatic vessel formation. Blood and lymphatic vessels form...

Job listing information

  • Reference MED01983
  • Date posted 19 August 2020
  • Closing date 22 September 2020

Job description

Job summary

We are seeking a highly motivated postdoctoral scientist to join a collaborative team of research scientists interested in vascular biology.

This British Heart Foundation-funded research project, led by Dr Graeme Birdsey at the National Heart and Lung Institute, will investigate the role of the transcription factor ERG in regulating lymphatic endothelial cell gene expression and lymphatic vessel formation.

Blood and lymphatic vessels form interconnected networks that are essential for transport of fluids, gases, macromolecules and cells. Dysfunction of lymphatic vessels leads to disturbed tissue fluid balance and lymphoedema. The lymphatic vasculature is of growing interest in terms of its development across organ systems and roles in primary and secondary lymphatic diseases and in response to tissue injury (e.g. myocardial infarction). Understanding the molecular regulation of lymphatic endothelial cell specification and lymphatic vessel formation (lymphangiogenesis) is important to underpin strategies to therapeutically modulate the lymphatics across these different disease settings.

ERG is the most highly expressed ETS transcription factor in healthy blood vessel endothelial cells (EC) and our previous work has defined the role of ERG as a master regulator of endothelial homeostasis, EC lineage specification and angiogenesis. These studies have been published in high impact papers in Blood, Developmental Cell, Nature Communications and Circulation Research. Although ECs line both vessels, ERG’s role in regulating lymphatic EC (LEC) gene expression and lymphangiogenesis is unknown.

Duties and responsibilities

The aim of this project is to investigate the cellular and molecular pathways that control lymphatic vessel development and lymphatic disease pathogenesis. You will define the signalling networks controlled by ERG in LEC and characterise the molecular targets and functional pathways involved in ERG-dependent lymphangiogenesis in health and disease. The project combines biochemical studies, transgenic inducible lineage-specific mouse models, ex vivo tissue processing and immunofluorescence confocal imaging, together with primary LEC culture for in vitro signalling and molecular cell biology. It will involve the generation and bioinformatics analysis of ChIP-Seq and RNA-Seq data sets.

Essential requirements

You should have a PhD in a relevant biological discipline and have experience in studying signalling pathways. You will have a track record of successful research, evidenced by first-authored research papers, published in highly reputable journals. A strong background in biochemistry and familiarity with primary cell culture and molecular biology techniques is essential. Previous experience in cardiovascular research is desirable, alongside a background using in vivo models for angiogenesis or lymphangiogenesis research. Knowledge of gene transcription pathways and bioinformatics analysis would be desirable.

The post will require collaboration with other groups both within and outside the department, and the ability to coordinate research projects with colleagues inside and outside the College. Enthusiasm, drive and a passion for science is essential for this position

Further information

The post is full-time and fixed-term for 3 years. 

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £35,477 - £38,566 per annum.

For more details of the research carried out within the NHLI Vascular Sciences Section, see https://www.imperial.ac.uk/nhli/research/research-sections/vascular-science/.

Should you require any further details on the role please contact: Dr Graeme Birdsey – g.birdsey@imperial.ac.uk.

For technical issues when applying online please email recruitment@imperial.ac.uk.

Committed to equality and valuing diversity, we are an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

All Imperial employees are expected to follow the 7 principles of Imperial Expectations: 

  • Champion a positive approach to change and opportunity
  • Communicate regularly and effectively within, and across, teams
  • Consider the thoughts and expectations of others
  • Deliver positive outcomes
  • Encourage inclusive participation and eliminate discrimination
  • Develop and grow skills and expertise
  • Work in a planned and managed way 

In addition to the above, employees are required to observe and comply with all College policies and regulations.

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.