Clinical Research Fellow

Job summary

This is an exciting 3 year full-time Clinical Research Fellow post, in the field of hormonal control of eating and addictive behaviours, at the PsychoNeuroEndocrinology Research Group (www.imperial.ac.uk/people/tony.goldstone) in the Department of Brain Sciences, Imperial College London (www.imperial.ac.uk/brain-sciences/research/psychiatry). You will work as the study clinician for an MRC-funded research grant, entitled “Human experimental...

Job listing information

  • Reference MED02053
  • Date posted 30 October 2020
  • Closing date 30 November 2020

Job description

Job summary

This is an exciting 3 year full-time Clinical Research Fellow post, in the field of hormonal control of eating and addictive behaviours, at the PsychoNeuroEndocrinology Research Group (www.imperial.ac.uk/people/tony.goldstone) in the Department of Brain Sciences, Imperial College London (www.imperial.ac.uk/brain-sciences/research/psychiatry).

You will work as the study clinician for an MRC-funded research grant, entitled “Human experimental medicine studies of gut hormone LEAP2, an endogenous ghrelin antagonist and target for obesity, diabetes, cachexia and addiction”.

This builds on our recently published paper which demonstrated that the newly discovered gut hormone LEAP2 is a natural antagonist of the orexigenic stomach-derived hormone acyl ghrelin [Mani BK, … Goldstone AP, Zigman JM. LEAP2 changes with body mass and food intake in humans and mice. J Clin Invest 129:3909-3923, 2019. www.jci.org/articles/view/125332]. We have shown that plasma LEAP2 concentrations fall when people fast or lose weight, and changes in plasma LEAP2 in humans mimicked those seen in mice.

Duties and responsibilities

As the study clinician, you will work with healthy volunteers who will receive intravenous hormone infusions. You will assist with participant recruitment, telephone screening, screening visits to assess eligibility through inclusion / exclusion criteria, medical history taking and examination, performance of study visits, data collection, processing and analysis.

You will perform intravenous cannula insertion, blood sampling, blood sample handling, provide medical cover, administer intravenous peptide infusions, and help perform the computer-based behavioural tests, on-line questionnaires and ratings, dietary assessments, and structural and functional MRI scans. You will assist with performing and analysing results from hormone immunoassays. Appropriate training will be given in all aspects of the study.

You will hold an honorary clinical contract with Imperial College Healthcare NHS Trust. No other non-research clinical commitments will be needed during the post.

Essential requirements

You should apply if you are a trainee interested in doing translational academic clinical research in a top 10 international University and want to register for a higher degree e.g. MD or PhD. You would likely be a specialist registrar (holding a GMC registration), training in Endocrinology, Metabolic Medicine, Psychiatry, Gastroenterology or General Internal Medicine, at ST3 grade or above (i.e. completed core medical training).

Further information

The proposed start date is 4th January 2021. This is a full-time, fixed-term appointment until 31st December 2023.

Interviews are to be held during week commencing 14th December 2020.

Salary: £34,466 - £42,969 (plus £2,162 London allowance pa)

You will be able to register for a higher degree e.g. MD or PhD.

You must hold a Medical qualification with registration at the General Medical Council.

As this post is exempt from the Rehabilitation of Offenders Act 1974, a satisfactory Disclosure and Barring Service (DBS) check, at the appropriate level, will be required for the successful candidate.

Should you require any further details on the role please email Dr. Tony Goldstone at tony.goldstone@imperial.ac.uk (or telephone 020 7594 5989).

For technical issues when applying online please email recruitment@imperial.ac.uk

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

All Imperial employees are expected to follow the 7 principles of Imperial Expectations: 

  • Champion a positive approach to change and opportunity
  • Communicate regularly and effectively within, and across, teams
  • Consider the thoughts and expectations of others
  • Deliver positive outcomes
  • Encourage inclusive participation and eliminate discrimination
  • Develop and grow skills and expertise
  • Work in a planned and managed way 

In addition to the above, employees are required to observe and comply with all College policies and regulations.

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.