Research Associate

Job summary

We are seeking a highly motivated Postdoctoral Research Associate to work in the Section of Molecular Microbiology, which is part of the Centre for Molecular Bacteriology and Infection (CMBI) at Imperial College London. The position is funded through a MRC grant. The research project will decipher the impact of phages in the emergence of antibiotic resistant bacteria, and the work will be conducted in the state-of-the-art laboratory of...

Job listing information

  • Reference MED02542
  • Date posted 28 June 2021
  • Closing date 26 July 2021

Job description

Job summary

We are seeking a highly motivated Postdoctoral Research Associate to work in the Section of Molecular Microbiology, which is part of the Centre for Molecular Bacteriology and Infection (CMBI) at Imperial College London.

The position is funded through a MRC grant. The research project will decipher the impact of phages in the emergence of antibiotic resistant bacteria, and the work will be conducted in the state-of-the-art laboratory of Professor José R Penadés. Bacteriophage-mediated gene transfer is a major evolutionary force occurring by two well-described mechanisms: generalized and specialized transduction.

We have recently discovered that Staphylococcus aureus phages engage in lateral transduction, the most powerful mode of transduction described to date. Lateral transduction converts large regions of the bacterial chromosome into “hypermobile platforms” for the high frequency transfer of any genetic element within their boundaries. Bacterial DNA is transferred at astonishingly high frequencies that are at least 1,000 times greater than any known mechanism of transduction.

Duties and responsibilities

The observed efficiency of chromosomal DNA transfer is unprecedented, representing a paradigm shift in phage biology and in the definition of mobile genetic elements. In this project, analysing important pathogens, we will investigate whether this ground-breaking strategy of gene transfer is widespread in nature.

We anticipate that the results of this study will challenge basic and fundamental concepts of phage biology, which will be revisited here. Moreover, the proposed research has the potential to fundamentally restructure our understanding of the roles of bacteriophages in bacterial evolution, including the development of antimicrobial resistance and virulence in clinical strains. 

Essential requirements

You will have a PhD or equivalent in Microbiology, Molecular Biology, Biochemistry or a related field. You will also have knowledge in the genetic manipulation of bacteria and previous experience working with bacteriophages and/or pathogenicity islands is desirable. You will also have experience within an academic research environment and a proven track record with publication in relevant and peer reviewed high-quality journals.

Further information

If you required additional information for the post, please, contact j.penades@imperial.ac.uk

For technical issues applying please contact: support.jobs@imperial.ac.uk

Interviews are expected to be held in Mid August 2021

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

All Imperial employees are expected to follow the 7 principles of Imperial Expectations: 

  • Champion a positive approach to change and opportunity
  • Communicate regularly and effectively within, and across, teams
  • Consider the thoughts and expectations of others
  • Deliver positive outcomes
  • Encourage inclusive participation and eliminate discrimination
  • Develop and grow skills and expertise
  • Work in a planned and managed way 

In addition to the above, employees are required to observe and comply with all College policies and regulations.

We are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment for all. We therefore encourage candidates to apply irrespective of age, disability, marriage or civil partnership status, pregnancy or maternity, race, religion and belief, gender identity, sex, or sexual orientation. We are an Athena SWAN Silver Award winner, a Disability Confident Leader and a Stonewall Diversity Champion.

For technical issues when applying online please email support.jobs@imperial.ac.uk.