Research Associate

Job summary

Applications are invited for the post of post-doctoral Research Associate in the Section of Virology within the Department of Infectious Disease, Imperial College London. Human immunodeficiency virus and human T-cell lymphotropic virus type 1 (HTLV-1) are the most notorious retroviruses since they are the cause of severe, disabling and sometimes fatal diseases. Ten to 20 million people worldwide are infected with HTLV-1. Of these individuals,...

Job listing information

  • Reference MED02693
  • Date posted 2 September 2021
  • Closing date 23 September 2021

Job description

Job summary

Applications are invited for the post of post-doctoral Research Associate in the Section of Virology within the Department of Infectious Disease, Imperial College London.

Human immunodeficiency virus and human T-cell lymphotropic virus type 1 (HTLV-1) are the most notorious retroviruses since they are the cause of severe, disabling and sometimes fatal diseases. Ten to 20 million people worldwide are infected with HTLV-1. Of these individuals, about 10% will become ill. The most severe HTLV-1 induced diseases are a neurological inflammatory disease and an aggressive form of leukaemia-lymphoma. So far, no good treatments of HTLV-1 infected patients are available. Patients diagnosed with leukaemia typically die within two years of presentation.

One essential step in the life cycle of retroviruses, such as HTLV-1, is the insertion of a copy of the viral genome into the host DNA. This process is executed by the viral integrase protein. We recently identified a host factor for HTLV-1 integration, PP2A-B56 (Maertens, G.N. NAR 2016; Barski, M.S. et al Nat. Comms, 2020). This project focuses on understanding the contribution and mechanics of the PP2A-B56 host factor in establishing HTLV-1 infection.

Duties and responsibilities

The position is supported by the Medical Research Council. You will focus on characterising the role and mechanism of host factors in HTLV integration. Various genetic, molecular and biochemical techniques, including next generation sequencing (NGS), DamID-seq, ChIPseq and RNAseq approaches will be used. You will be in an excellent position to carry out research in the competitive field of retrovirology.

Essential requirements

The project requires an exceptionally motivated scientist with a PhD in a relevant area, and a solid background in molecular biology and biochemistry techniques, preferably with experience in retrovirology.

Good experience with RNA sequencing and NGS analysis, working with R and/or experience with molecular retroviral work would be an advantage. You will have the opportunity to design and implement experimental strategies and to develop the project.

You will have good interpersonal and presentation skills and will also be required to train/assist other members of the laboratory. In addition, you will be expected to submit publications to refereed journals, and to present your findings at international and national conferences.          

Further information

For more information on the background of the project, visit this website: http://www.imperial.ac.uk/people/g.maertens

Informal enquiries may be made to Dr Goedele N. Maertens at g.maertens@imperial.ac.uk

Disclosure and Barring Service (DBS) check if required

 

As this post is exempt from the Rehabilitation of Offenders Act 1974, a satisfactory Disclosure and Barring Service (DBS) check, at the appropriate level, will be required for the successful candidate.

Further information about the DBS disclosure process can be found at http://www.homeoffice.gov.uk/agencies-public-bodies/dbs/ or by telephoning 03000 200 190. You may also wish to view the College’s DBS webpage for policy statements on the Recruitment and Employment of Ex-Offenders and the Secure Storage, Use, Retention & Disposal of Disclosures and Disclosure Information.

 

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

 

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

All Imperial employees are expected to follow the 7 principles of Imperial Expectations: 

  • Champion a positive approach to change and opportunity
  • Communicate regularly and effectively within, and across, teams
  • Consider the thoughts and expectations of others
  • Deliver positive outcomes
  • Encourage inclusive participation and eliminate discrimination
  • Develop and grow skills and expertise
  • Work in a planned and managed way 

In addition to the above, employees are required to observe and comply with all College policies and regulations.

We are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment for all. We therefore encourage candidates to apply irrespective of age, disability, marriage or civil partnership status, pregnancy or maternity, race, religion and belief, gender identity, sex, or sexual orientation. We are an Athena SWAN Silver Award winner, a Disability Confident Leader and a Stonewall Diversity Champion.

For technical issues when applying online please email support.jobs@imperial.ac.uk.