Research Associate in Epigenomics
The laboratory of Dr Raffaella Nativio at the UK DRI at Imperial is seeking a bright, talented, highly motivated, and ambitious postdoctoral scientist to lead one or more projects investigating basic mechanisms of epigenetic regulation and their involvement in aging and age-related neurodegeneration. While aging is the top risk factor for neurodegeneration, the underlying mechanisms have remained unclear. The epigenetic state has been...
Job listing information
- Reference MED02721
- Date posted 14 September 2021
- Closing date 31 October 2021
The laboratory of Dr Raffaella Nativio at the UK DRI at Imperial is seeking a bright, talented, highly motivated, and ambitious postdoctoral scientist to lead one or more projects investigating basic mechanisms of epigenetic regulation and their involvement in aging and age-related neurodegeneration.
While aging is the top risk factor for neurodegeneration, the underlying mechanisms have remained unclear. The epigenetic state has been implicated in aging and lifespan of lower organisms and thus may play a pivotal role in age-related neurodegeneration. We previously identified histone posttranslational modification changes associated with healthy aging or Alzheimer’s disease (Nativio et al., Nature Neuroscience, 2018; Nativio et al., Nature Genetics, 2020). Next, we aim to investigate the epigenetic pathways, that by modulating environmental, metabolic and genetic risk, predispose or protect from neurodegeneration during the course of aging. Given the association of genetic risk variants with long-distance regulatory elements, such as enhancers, we will also explore the role of genome conformation in aging and neurodegeneration.
The successful candidate will be familiar with the biology of epigenetic regulation and proficient in using genomic/epigenomic approaches (ChIP-seq, RNA-seq, ATAC-seq, CUT&RUN, CUT&Tag, HiC or HiChIP), gene editing tools (CRISPR/Cas9 or CRISPRi/CRISPRa), and induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs) culture systems.
Duties and responsibilities
- To take initiatives in the planning of research
- To actively participate in the research programme of the Group
- To plan and conduct own scientific work, with appropriate supervision
- To identify and develop suitable techniques for the collection and analysis of data
- To conduct data analysis
- To ensure the validity and reliability of data at all times
- To maintain highly organised, accurate and complete records of all experimental work
- To present findings in regular group meetings to the PI and colleagues
- To prepare and present reports
- To present findings to colleagues and at conferences
- To submit publications to high quality, refereed journals
- To provide guidance to staff and students, providing supervision as required
- To attend relevant workshops and conferences as necessary
- To participate in Group/Centre research meetings and internal seminars
- To develop contacts and research collaborations within the College, the UK DRI and the wider community
- Research Associate: Hold a PhD (or equivalent) in Biological Sciences (e.g., Molecular Biology, Biochemistry) or a closely related discipline, or equivalent research or industrial experience
- Research Assistant: Near completion of a PhD (or equivalent) in Biological Sciences (e.g., Molecular Biology, Biochemistry) or a closely related discipline, or equivalent research or industrial experience
- Practical experience within a research environment and/or publication in relevant and refereed journals
- Practical experience in a broad range of genomics/epigenomics techniques including ChIP-seq, ATAC-seq, RNA-seq, CUT&RUN, CUT&Tag, chromosome conformation capture-based methods such as 3C, HiC and HiChIP
- Demonstrable experience with cell culture models including cultures of primary neurons and iPSC-derived neurons, microglia or astrocytes
This is a Full Time & Fixed Term post offered initially for 12 months, with potential for extension. The post will be based in the Department of Brain Sciences with research labs in the Burlington Danes Building of Hammersmith Campus and the new UK DRI research labs at the White City Campus in West London.
Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,694 - £39,888 per annum.
Should you have any queries please contact Dr Raffaella Nativio at firstname.lastname@example.org
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