Research Associate in Epigenomics

Job summary

The laboratory of Dr Raffaella Nativio at the UK DRI at Imperial is seeking a bright, talented, highly motivated, and ambitious postdoctoral scientist to lead one or more projects investigating basic mechanisms of epigenetic regulation and their involvement in aging and age-related neurodegeneration. While aging is the top risk factor for neurodegeneration, the underlying mechanisms have remained unclear. The epigenetic state has been...

Job listing information

  • Reference MED02721
  • Date posted 14 September 2021
  • Closing date 31 October 2021

Job description

Job summary

The laboratory of Dr Raffaella Nativio at the UK DRI at Imperial is seeking a bright, talented, highly motivated, and ambitious postdoctoral scientist to lead one or more projects investigating basic mechanisms of epigenetic regulation and their involvement in aging and age-related neurodegeneration.

While aging is the top risk factor for neurodegeneration, the underlying mechanisms have remained unclear. The epigenetic state has been implicated in aging and lifespan of lower organisms and thus may play a pivotal role in age-related neurodegeneration. We previously identified histone posttranslational modification changes associated with healthy aging or Alzheimer’s disease (Nativio et al., Nature Neuroscience, 2018; Nativio et al., Nature Genetics, 2020). Next, we aim to investigate the epigenetic pathways, that by modulating environmental, metabolic and genetic risk, predispose or protect from neurodegeneration during the course of aging. Given the association of genetic risk variants with long-distance regulatory elements, such as enhancers, we will also explore the role of genome conformation in aging and neurodegeneration.

The successful candidate will be familiar with the biology of epigenetic regulation and proficient in using genomic/epigenomic approaches (ChIP-seq, RNA-seq, ATAC-seq, CUT&RUN, CUT&Tag, HiC or HiChIP), gene editing tools (CRISPR/Cas9 or CRISPRi/CRISPRa), and induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs) culture systems.

Duties and responsibilities


  • To take initiatives in the planning of research

  • To actively participate in the research programme of the Group

  • To plan and conduct own scientific work, with appropriate supervision

  • To identify and develop suitable techniques for the collection and analysis of data

  • To conduct data analysis

  • To ensure the validity and reliability of data at all times

  • To maintain highly organised, accurate and complete records of all experimental work

  • To present findings in regular group meetings to the PI and colleagues

  • To prepare and present reports

  • To present findings to colleagues and at conferences

  • To submit publications to high quality, refereed journals

  • To provide guidance to staff and students, providing supervision as required

  • To attend relevant workshops and conferences as necessary

  • To participate in Group/Centre research meetings and internal seminars

  • To develop contacts and research collaborations within the College, the UK DRI and the wider community

Essential requirements


  • Research Associate: Hold a PhD (or equivalent) in Biological Sciences (e.g., Molecular Biology, Biochemistry) or a closely related discipline, or equivalent research or industrial experience

  • Research Assistant: Near completion of a PhD (or equivalent) in Biological Sciences (e.g., Molecular Biology, Biochemistry) or a closely related discipline, or equivalent research or industrial experience

  • Practical experience within a research environment and/or publication in relevant and refereed journals

  • Practical experience in a broad range of genomics/epigenomics techniques including ChIP-seq, ATAC-seq, RNA-seq, CUT&RUN, CUT&Tag, chromosome conformation capture-based methods such as 3C, HiC and HiChIP

  • Demonstrable experience with cell culture models including cultures of primary neurons and iPSC-derived neurons, microglia or astrocytes

Further information

This is a Full Time & Fixed Term post offered initially for 12 months, with potential for extension.  The post will be based in the Department of Brain Sciences with research labs in the Burlington Danes Building of Hammersmith Campus and the new UK DRI research labs at the White City Campus in West London.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,694 - £39,888 per annum.

Should you have any queries please contact Dr Raffaella Nativio at r.nativio@imperial.ac.uk

 

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see: https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level.

http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

All Imperial employees are expected to follow the 7 principles of Imperial Expectations: 

  • Champion a positive approach to change and opportunity
  • Communicate regularly and effectively within, and across, teams
  • Consider the thoughts and expectations of others
  • Deliver positive outcomes
  • Encourage inclusive participation and eliminate discrimination
  • Develop and grow skills and expertise
  • Work in a planned and managed way 

In addition to the above, employees are required to observe and comply with all College policies and regulations.

We are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment for all. We therefore encourage candidates to apply irrespective of age, disability, marriage or civil partnership status, pregnancy or maternity, race, religion and belief, gender identity, sex, or sexual orientation. We are an Athena SWAN Silver Award winner, a Disability Confident Leader and a Stonewall Diversity Champion.

For technical issues when applying online please email support.jobs@imperial.ac.uk.