This is an exciting role in the development of a new fluorescence probes for Heme Oxygenase 1 (HO-1). It follows up our recent publication in Journal of the American Chemical Society. It next takes this work into more complex biological systems. Dr Boyle’s group focusses on the regulation, detection and effects of Heme Oxygenase 1, in macrophages in cardiovascular disease. You will assess novel fluorescent chemical probes of HO-1, in...
Job listing information
- Reference MED02747
- Date posted 12 October 2021
- Closing date 26 October 2021
This is an exciting role in the development of a new fluorescence probes for Heme Oxygenase 1 (HO-1). It follows up our recent publication in Journal of the American Chemical Society. It next takes this work into more complex biological systems. Dr Boyle’s group focusses on the regulation, detection and effects of Heme Oxygenase 1, in macrophages in cardiovascular disease.
You will assess novel fluorescent chemical probes of HO-1, in fluorescence enzyme assays in cell lysates, cells, tissues and eventually transcutaneous imaging in our published in vivo models. You will discuss results with Dr Boyle and the chemistry team on the same project. Your data and potentially ideas will feed back in real time to creation of new probes with improved properties. You will also use these probes to test interesting new hypotheses in cell biology. This will involve close liaison between the post-holder with line manager Dr Boyle, the recently-appointed chemistry post-doc (Saul Cooper) and Prof Nick Long and Ed Walter. There are several biological questions that the novel probes may answer, and we anticipate several quality publications, in addition to the core objective of probe validation. Chemical fluorescence probes for specific biochemical measurements are increasingly popular. This will be the first such probe for HO-1, a major anti-oxidant enzyme that is a marker of hemorrhage-response protective macrophages, Mhem.
Duties and responsibilities
- The post is funded by a peer-reviewed Project Grant and the pursuit of the Aims of the Project are the primary function for you.
- To comply with the College, Division, and Unit safety practices and to attend courses on safety when appropriate.
- To identify and develop suitable techniques, and apparatus, for the collection and analysis of data
- To conduct data analysis
- To ensure the validity and reliability of data at all times
- To maintain accurate and complete records of all findings
- To help write and submit publications to refereed journals
- To supervise students and thereby help direct the work of a small research team
- To present findings to colleagues and at conferences
- To help write reports for submission to research sponsors
- To provide guidance to staff and students
- Research Associate: Hold a PhD (or equivalent) in Biochemistry, Pharmacology or a closely related discipline.
- Research Assistant: Near completion of a PhD (or equivalent) in Biochemistry, Pharmacology, or a closely related discipline.
- Knowledge of macrophages, fluorescence probes, enzymes
- Knowledge of research methods and statistical procedures
- Practical experience within a research environment and / or publication in relevant and refereed journals
- Dealing with specific groups of people, e.g., sponsors, chemists, CBS staff
- Practical experience in a broad range of techniques including optical measurement, fluorescence measurements, enzymology, microscopy
This is a Full Time and Fixed term contract for 18 months, based at the Hammersmith Campus.
Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,694 - £39,888 per annum
Should you require any further details on the role please contact: Joseph (Joe) Boyle – firstname.lastname@example.org.
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