Research Associate

Job summary

  This is an exciting role in the development of a new fluorescence probes for Heme Oxygenase 1 (HO-1). It follows up our recent publication in Journal of the American Chemical Society. It next takes this work into more complex biological systems. Dr Boyle’s group focusses on the regulation, detection and effects of Heme Oxygenase 1, in macrophages in cardiovascular disease. You will assess novel fluorescent chemical probes of HO-1, in...

Job listing information

  • Reference MED02747
  • Date posted 12 October 2021
  • Closing date 26 October 2021

Job description

Job summary

 

This is an exciting role in the development of a new fluorescence probes for Heme Oxygenase 1 (HO-1). It follows up our recent publication in Journal of the American Chemical Society. It next takes this work into more complex biological systems. Dr Boyle’s group focusses on the regulation, detection and effects of Heme Oxygenase 1, in macrophages in cardiovascular disease.

You will assess novel fluorescent chemical probes of HO-1, in fluorescence enzyme assays in cell lysates, cells, tissues and eventually transcutaneous imaging in our published in vivo models. You will discuss results with Dr Boyle and the chemistry team on the same project. Your data and potentially ideas will feed back in real time to creation of new probes with improved properties. You will also use these probes to test interesting new hypotheses in cell biology. This will involve close liaison between the post-holder with line manager Dr Boyle, the recently-appointed chemistry post-doc (Saul Cooper) and Prof Nick Long and Ed Walter. There are several biological questions that the novel probes may answer, and we anticipate several quality publications, in addition to the core objective of probe validation. Chemical fluorescence probes for specific biochemical measurements are increasingly popular. This will be the first such probe for HO-1, a major anti-oxidant enzyme that is a marker of hemorrhage-response protective macrophages, Mhem.

Duties and responsibilities


  • The post is funded by a peer-reviewed Project Grant and the pursuit of the Aims of the Project are the primary function for you.

  • To comply with the College, Division, and Unit safety practices and to attend courses on safety when appropriate.

  • To identify and develop suitable techniques, and apparatus, for the collection and analysis of data

  • To conduct data analysis

  • To ensure the validity and reliability of data at all times

  • To maintain accurate and complete records of all findings

  • To help write and submit publications to refereed journals

  • To supervise students and thereby help direct the work of a small research team

  • To present findings to colleagues and at conferences

  • To help write reports for submission to research sponsors

  • To provide guidance to staff and students

Essential requirements


  • Research Associate: Hold a PhD (or equivalent) in Biochemistry, Pharmacology or a closely related discipline.

  • Research Assistant: Near completion of a PhD (or equivalent) in Biochemistry, Pharmacology, or a closely related discipline.

  • Knowledge of macrophages, fluorescence probes, enzymes

  • Knowledge of research methods and statistical procedures

  • Practical experience within a research environment and / or publication in relevant and refereed journals

  • Dealing with specific groups of people, e.g., sponsors, chemists, CBS staff

  • Practical experience in a broad range of techniques including optical measurement, fluorescence measurements, enzymology, microscopy

Further information

This is a Full Time and Fixed term contract for 18 months, based at the Hammersmith Campus.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,694 - £39,888 per annum

Should you require any further details on the role please contact: Joseph (Joe) Boyle – joseph.boyle@imperial.ac.uk.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level.

http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive, and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

Imperial College is committed to equality of opportunity and to eliminating discrimination. All employees are expected to follow the Imperial Values & Behaviours framework. Our values are: 

  • Respect              
  • Collaboration
  • Excellence          
  • Integrity
  • Innovation

In addition to the above, employees are required to observe and comply with all College policies and regulations.

We are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment for all. We therefore encourage candidates to apply irrespective of age, disability, marriage or civil partnership status, pregnancy or maternity, race, religion and belief, gender identity, sex, or sexual orientation. We are an Athena SWAN Silver Award winner, a Disability Confident Leader and a Stonewall Diversity Champion.

For technical issues when applying online please email support.jobs@imperial.ac.uk.