Research Associate in Epigenetics - UK Dementia Research Institute

Job summary

To date there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it. The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap. We are a globally leading multidisciplinary research institute of 700 staff investigating the spectrum of neurodegenerative disorders causing dementia,...

Job listing information

  • Reference MED02809
  • Date posted 26 October 2021
  • Closing date 4 January 2022

Job description

Job summary

To date there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it.

The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap.

We are a globally leading multidisciplinary research institute of 700 staff investigating the spectrum of neurodegenerative disorders causing dementia, with laboratory-based research groups located at Imperial College London, University College London, the University of Cambridge, Cardiff University, Edinburgh University, and King’s College London.

The research group of Dr Nathan Skene in the UK DRI at Imperial College London addresses key questions about the mechanisms of neurodegenerative disease.  In a series of recent publications in Nature Genetics, the lab has demonstrated that single cell RNA-seq data from mice can be used to identify the cell types associated with genetic risk factors for neurodegenerative disease. We aim to develop single cell epigenetic techniques, such as ATAC-seq and CUT&TAG, to enhance our ability to map intergenic loci to cell type specific features.

Postdocs at the UK DRI at Imperial enjoy excellent career development opportunities including the opportunity to supervise and teach students, access to new, purpose-built laboratory space, and a collegial, team-oriented working environment.  Imperial is the UK’s most international university and welcomes staff from all backgrounds and from all over the world.  Support is available for the visa application process and fees and eligible candidates are encouraged to apply for a Global Talent Visa.

Duties and responsibilities

Prior experience in cellular genomics methods and a strong background in neurobiology will be assets. You’ll be proficient in using genomic/epigenomic approaches and a range of molecular methods for brain tissue analysis. Depending on the project you will have the opportunity to gain experience with the biology of epigenetic regulation and induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs) culture systems. 

Essential requirements


  • Research Associate: Hold a PhD (or equivalent) in Biochemistry, Molecular Biology or a closely related discipline, or equivalent research, industrial or commercial experience

  • Research Assistant: Near completion of a PhD (or equivalent) in Biochemistry, Molecular Biology or a closely related discipline, or equivalent research, industrial or commercial experience

  • Evidence for mastery of laboratory-based molecular biology skills

  • Experience with some genomic techniques including but not limited to ATAC-seq, RNA-seq, DNase-seq, MNase-seq, CUT&TAG, CUT&RUN, Radicl-seq or Hi-C.

Further information

This is a Full Time and Fixed Term contract being offered initially for 12 months with potential for extension for a further 5 years.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,694 - £39,888 per annum.

Applicants are strongly encouraged to contact Dr Nathan Skene for informal discussion about the role at n.skene@imperial.ac.uk  

For more information about the UK DRI at Imperial, please visit:

http://www.imperial.ac.uk/dementia-research-institute

Dr Skene’s research website: https://www.neurogenomics.co.uk/

The UK Dementia Research Institute: https://ukdri.ac.uk/

Committed to equality and valuing diversity, we are also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and are working in partnership with GIRES to promote respect for trans people.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive, and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

Imperial College is committed to equality of opportunity and to eliminating discrimination. All employees are expected to follow the Imperial Values & Behaviours framework. Our values are: 

  • Respect              
  • Collaboration
  • Excellence          
  • Integrity
  • Innovation

In addition to the above, employees are required to observe and comply with all College policies and regulations.

We are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment for all. We therefore encourage candidates to apply irrespective of age, disability, marriage or civil partnership status, pregnancy or maternity, race, religion and belief, gender identity, sex, or sexual orientation. We are an Athena SWAN Silver Award winner, a Disability Confident Leader and a Stonewall Diversity Champion.

For technical issues when applying online please email support.jobs@imperial.ac.uk.