Research Associate

Job summary

The Lloyd lab, funded by the Wellcome Trust, has embarked on a multidisciplinary project to investigate neuro-immune-stromal interactions in response to environmental change, and how this drives allergic airway inflammation and remodelling. We use patient samples and neonatal/adult allergic airway mouse models to determine immune-neuro interactions and assess their impact on disease progression, pathology, and lung function...

Job listing information

  • Reference MED03283
  • Date posted 11 November 2022
  • Closing date 9 December 2022

Job description

Job summary

The Lloyd lab, funded by the Wellcome Trust, has embarked on a multidisciplinary project to investigate neuro-immune-stromal interactions in response to environmental change, and how this drives allergic airway inflammation and remodelling.

We use patient samples and neonatal/adult allergic airway mouse models to determine immune-neuro interactions and assess their impact on disease progression, pathology, and lung function (www.lloydlab.co.uk)

To fully comprehend the complex interactions between the different cellular compartments in lungs, we are looking for an individual to develop and drive the integration of advanced imaging technologies and spatial transcriptomics. Data analysis will be a key component of this project and therefore a keen interest in mining complex data sets will be essential.

Duties and responsibilities


  • Actively participate in the research programme of the Lloyd Group

  • Conduct and plan own scientific work

  • Identify and develop techniques, software, equipment for the collection and analysis of data

  • Assist in the supervision of students and research assistants

  • To publish in high quality journals and to present data at national and international meetings

Essential requirements

The successful candidate will have a PhD in a related discipline, and be technically proficient in a range of laboratory skills, have the ambition and drive to succeed.

Research Associate: Hold a PhD in Immunology or a closely related discipline.

Research Assistant: Near completion of a PhD in Immunology or a closely related discipline.

*Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant.

  • Extensive Microscopy experience (Confocal, widefield, live cell imaging, intravital or IMC). Knowledge or experience of Second Harmonic Generation microscopy would be advantageous.
  • Image Analysis and associated software including Image J, ICY, IMARIS, Huygens, Volocity, MCD, Cell Profiler, ilastik.
  • Experience of single cell or bulk RNAseq, NGS, Spatial Transcriptomics or proteomics would be advantageous as would experience using R and/or python code for bioinformatics data analysis of multiplex datasets. Knowledge of MATLAB, Perl, CellPhoneDB, CellChat, NicheNet, Seurat.
  • In vivo experience, preferably with a home office license - PIL A,B and C.

This post will provide the opportunity to develop and drive a research project as well as writing up work for presentation and publication. Therefore, the ability to work independently and as part of a team, have excellent communication, organisational and problem-solving skills are essential.

Further information

This is a full time and fixed term post until July 2026. You will be based at the South Kensington Campus.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £38,194 - £41,388 per annum.

Should you require any further details on the role please contact: Laura Yates, Research Manager Lloyd Lab -  l.yates@imperial.ac.uk.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level.

http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive, and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

Imperial College is committed to equality of opportunity and to eliminating discrimination. All employees are expected to follow the Imperial Values & Behaviours framework. Our values are: 

  • Respect              
  • Collaboration
  • Excellence          
  • Integrity
  • Innovation

In addition to the above, employees are required to observe and comply with all College policies and regulations.

We are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment for all. We therefore encourage candidates to apply irrespective of age, disability, marriage or civil partnership status, pregnancy or maternity, race, religion and belief, gender reassignment, sex, or sexual orientation. We are an Athena SWAN Silver Award winner, a Disability Confident Leader and a Stonewall Diversity Champion.

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