Research Associate
Job summary
Applications are invited for an exciting Postdoctoral Research Associate position in the laboratory of Professor Speck at Imperial College London (http://www.specklab.com/). This post aims to uncover fundamental and medically relevant mechanisms that guarantee efficient human DNA replication employing cutting-edge biochemical and structural approaches. The project’s primary objective is to discover 1.) how DNA replication origins are...
Job listing information
- Reference MED04213
- Date posted 6 November 2023
- Closing date 3 January 2024
Job description
Job summary
Applications are invited for an exciting Postdoctoral Research Associate position in the laboratory of Professor Speck at Imperial College London (http://www.specklab.com/). This post aims to uncover fundamental and medically relevant mechanisms that guarantee efficient human DNA replication employing cutting-edge biochemical and structural approaches. The project’s primary objective is to discover 1.) how DNA replication origins are specified through epigenetic mechanisms and specific recruitment factors and 2.) how DNA replication is regulated to allow faithful DNA replication. The candidate will be able to take advantage of a recently established reconstituted system, which allows us to address these questions for the first time.
Who we are looking for:
We seek a creative researcher who enjoys tackling ambitious research questions. This project is ideal for a candidate who enjoys protein biochemistry, wants to learn cryo-EM/knows cryo-EM and wants to explore a new research area. Prior experience in the supervision of master students is an advantage. Professor Speck will mentor you in grant writing, networking and publishing
Duties and responsibilities
You will express and purify proteins and use these in sophisticated biochemical assays. An interest in cryo-EM or existing expertise in structural biology would be beneficial. We are well equipped for biochemistry (multiple AKTAs) and electron microscopy (Talos 200kV FEG cryo-EM Falcon 3, Vitrobot IV, GPU- and data storage-cluster and direct access to a Titan Krios with K3 detector)
Essential requirements
- PhD & a strong publication record (published or submitted) (*Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £38,194 - £41,388 per annum).
- Extensive expertise in protein biochemistry
- Strong knowledge in biochemical assays
- Ability to troubleshoot and work independently
- Background in molecular machines, nucleic acid-protein interactions, cell-cycle, chromatin-
Further information
This is a Full Time and fixed-term role for 3 years initially based at the Hammersmith Campus.
Should you require further information please contact: Christian Speck – chris.speck@imperial.ac.uk.
For technical issues when applying online please email support.jobs@imperial.ac.u
Documents
About Imperial College London
Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.
You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.
We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.
It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.
Additional information
Please note that job descriptions cannot be exhaustive, and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.
Imperial College is committed to equality of opportunity and to eliminating discrimination. All employees are expected to follow the Imperial Values & Behaviours framework. Our values are:
- Respect
- Collaboration
- Excellence
- Integrity
- Innovation
In addition to the above, employees are required to observe and comply with all College policies and regulations.
We are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment for all. We therefore encourage candidates to apply irrespective of age, disability, marriage or civil partnership status, pregnancy or maternity, race, religion and belief, gender reassignment, sex, or sexual orientation. We are an Athena SWAN Silver Award winner, a Disability Confident Leader and a Stonewall Diversity Champion.
For technical issues when applying online please email support.jobs@imperial.ac.uk.
Awards
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Top 10 employer for working families
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Race Equality Charter Bronze Award
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Imperial is a Disability Confident leader
