Research Associate in Hematopoietic Stem Cell Biology

Job summary

We are seeking to recruit an outstanding and highly motivated postdoctoral researcher to join the Haematopoietic Stem Cell Niche Laboratory, led by Dr Tiago C. Luis at the South Kensington Campus of Imperial College London. Our lab focuses on understanding the molecular mechanisms by which the bone marrow niche regulates haematopoietic stem cells (HSC) function in the maintenance of blood cells homeostasis and the development of haematological...

Job listing information

  • Reference NAT00474
  • Date posted 10 June 2019
  • Closing date 12 July 2019

Job description

Job summary

We are seeking to recruit an outstanding and highly motivated postdoctoral researcher to join the Haematopoietic Stem Cell Niche Laboratory, led by Dr Tiago C. Luis at the South Kensington Campus of Imperial College London.

Our lab focuses on understanding the molecular mechanisms by which the bone marrow niche regulates haematopoietic stem cells (HSC) function in the maintenance of blood cells homeostasis and the development of haematological malignancies. You will work on an exciting new project funded by the Wellcome Trust and The Royal Society aimed at understanding how myeloid leukaemia remodels the HSC niche to favour leukaemia development. This is a multidisciplinary project involving the use of in vivo models of leukaemia development, which will be analysed by cutting edge multi-parameter flow cytometry, single-cell RNA sequencing, imaging of the bone marrow niche and computational/systems biology methods to decode the molecular cross-talk between leukemic stem cells and the bone marrow niche. This project is part of an established collaboration with Dr. Cristina Lo Celso as well as other collaborators in this vibrant and multidisciplinary department and campus. For more details on our research please see the laboratory web site.

The Department of Life Sciences (DoLS) at Imperial College London, embraces the full breadth of modern life sciences activity, which is organized in 12 research themes. DoLS is located on 2 campuses at South Kensington and Silwood Park and is one of the largest life sciences groups in Europe. DoLS was the top ranked university department in the UK for research intensity in Biological Sciences in REF2014 Times Higher Education, scoring 100% on our environment.

Duties and responsibilities

You will drive your research project and will be responsible for running experiments and day-to-day project management and development. The project will involve a high degree of teamwork, interdisciplinary research and flexibility in developing and managing complex and demanding experimental protocols and data sets. Your main duties are described below:

 Main duties:

  • To be pro-active in planning and conducting the research work and to perform data analysis, with appropriate supervision;
  • To ensure the validity and reliability of data at all times;
  • To perform research that fulfils the requirements of the grant objective;
  • To present findings to colleagues, collaborators and at conferences;
  • To draft publications and prepare them for submission to peer reviewed journals;

Essential requirements


  • A PhD (or equivalent) in haematology, immunology, stem cell biology or related research field;


You must be able to demonstrate:


Experience with:



  • In vivo mouse models;

  • Flow Cytometry;

  • Gene expression analysis such as RT-qPCR and/or RNA sequencing;


Knowledge of:



  • Stem cell biology and/or haematopoiesis;

  • Research methods and data/statistical analysis in these fields;


Experience in Bioinformatics and imaging skills would be an asset.  

Further information

This is a full time, fixed term contract for 3 years.

For more information visit the laboratory web site. Should you require any further details on the role please contact Dr Tiago Luis (t.luis@imperial.ac.uk).

*Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant within the salary range £34,397 - £37,486 per annum.

For technical issues when applying online please email: recruitment@imperial.ac.uk.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research/

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

All Imperial employees are expected to follow the 7 principles of Imperial Expectations: 

  • Champion a positive approach to change and opportunity
  • Communicate regularly and effectively within, and across, teams
  • Consider the thoughts and expectations of others
  • Deliver positive outcomes
  • Encourage inclusive participation and eliminate discrimination
  • Develop and grow skills and expertise
  • Work in a planned and managed way 

In addition to the above, employees are required to observe and comply with all College policies and regulations.

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.