Critical care involves the care of the sickest patients in the hospital. Critically ill patients have usually been through a significant insult to their body (such as trauma, infection, burn) and have developed organ failure and require life-support. Critical Care is the largest theme bringing together clinicians and scientists from diverse backgrounds and includes collaborative research from hospitals throughout north-west London. Investigations range from evaluating biological mechanisms of organ failure through to the development of innovative technologies which allow the short-term and long-term support and recovery of organs.
Many people are exposed to the environment of an Intensive care unit (ICU) either personally or through a family member. It is often a life-changing event and our work aims to reduce this impact facilitating post-ICU recovery.
- Acute Respiratory Distress Syndrome (ARDS)
- Burn injury
- Extracorporeal life support
- Functional outcomes and health service research
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Journal articleO'Dea KP, Wilson MR, Dokpesi JO, et al., 2009,
Conference paperFletcher M, Takata M, Marczin N, 2008,
INHIBITORS OF GLUTATHIONE-S-TRANSFERASE INDUCE CELL DEATH IN LUNG EPITHELIAL CELLS, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A144-A144, ISSN: 0040-6376
Journal articleRippon HJ, Lane S, Qin M, et al., 2008,
Embryonic stem cells (ESCs) derived from the preimplantation blastocyst are pluripotent and capable of indefinite expansion in vitro. As such, they present a cell source to derive a potentially inexhaustible supply of pulmonary cells and tissue. ESC-derived pulmonary epithelium could be used for in vitro cell or tissue models or, in the future, implanted into the damaged or diseased lung to effect repair. Efforts to date have largely focused on obtaining distal lung epithelial phenotypes from ESCs, notably alveolar epithelium. Several disparate methods have been developed to enhance differentiation of ESCs into pulmonary epithelial lineages; these are broadly based on recapitulating developmental signaling events, mimicking the physical environment, or forcibly reprogramming the ESC nucleus. Early findings of our preclinical experiments implanting differentiated ESCs into the injured lung are also described here. Future efforts will focus on maximizing ESC differentiation efficiency and yield of the target phenotype, as well as characterizing the function of derived cells in vivo and in vitro.
Conference paperPinhu L, Wilson M, Takata M, et al., 2007,
Cyclo-oxygenase-2 induction by cyclic mechanical strain in human primary alveolar type 2 cells and in murine whole lung is dependent on activation of erk1/2, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A60-A61, ISSN: 0040-6376
Journal articleWilson MR, Goddard ME, O'Dea KP, et al., 2007,
Journal articleVizcaychipi MP, Burt C, Burnstein R, 2007,
Pulmonary embolism: An Unusual Cause Of Acute Liver Failure, The Internet Journal of Emergency and Intensive Care Medicine™ ISSN: 1092-4051, Vol: 10
Pulmonary embolism is still a challenging diagnosis and a very high index of suspicion is required. Symptoms and signs of acute right heart failure are still non-specific and often vary according to the precipitating condition. In this particular case, evolving liver failure and severe coagulation disorder as the initial presentation made the management of this patient very challenging and several causes of sudden decompensated liver failure were ruled out. Acute reduction of splanchnic flow was considered but in the context of relative good oxygenation and no history or clinical signs of deep venous thrombosis, the diagnosis of pulmonary embolism was not considered as a primary cause of liver failure and evolving multiple organ failure. Complementary studies, namely echocardiogram and use of a pulmonary artery catheter immediately raised the suspicion of a saddle pulmonary embolus. In view of the findings, an emergency contrast-enhanced spiral computed tomography was performed and the diagnosis of pulmonary embolism was made.
Journal articleTatham KC, 2006,
Reduce morbidity by balancing your fluids., British Journal of Hospital Medicine, Vol: 4
Journal articleGordon AC, Waheed U, Hansen TK, et al., 2006,
Journal articleO'Dea KP, Young AJ, Yamamoto H, et al., 2005,
Lung-marginated monocytes modulate pulmonary microvascular injury during early endotoxemia.
Journal articleUlrich K, Stern M, Goddard ME, et al., 2005,
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