Critical Care

Critical care wardCritical care involves the care of the sickest patients in the hospital. Critically ill patients have usually been through a significant insult to their body (such as trauma, infection, burn) and have developed organ failure and require life-support. Critical Care is the largest theme bringing together clinicians and scientists from diverse backgrounds and includes collaborative research from hospitals throughout north-west London. Investigations range from evaluating biological mechanisms of organ failure through to the development of innovative technologies which allow the short-term and long-term support and recovery of organs. 

Many people are exposed to the environment of an Intensive care unit (ICU) either personally or through a family member. It is often a life-changing event and our work aims to reduce this impact facilitating post-ICU recovery.

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  • Journal article
    Richardson AL, Vizcaychipi MP, 2014,

    Medicolegal aspects of treatment on the Intensive Care Unit

    , Trends in Anaesthesia and Critical Care, Vol: 4, Pages: 37-40, ISSN: 2210-8440

    Whether or not to offer treatment to a patient, is a dilemma that occurs throughout medicine. The decision to admit to the Intensive Care Unit for life-sustaining care, or for more limited treatment can be difficult. This article aims to cover consent for treatment, advance directives, and best interests, and the continued care that should be provided if the patient ends their life on the Intensive Care Unit. © 2013 Elsevier Ltd.
  • Journal article
    Tridente A, Clarke GM, Walden A, McKechnie S, Hutton P, Mills GH, Gordon AC, Holloway PAH, Chiche J-D, Bion J, Stuber F, Garrard C, Hinds CJet al., 2014,

    Patients with faecal peritonitis admitted to European intensive care units: an epidemiological survey of the GenOSept cohort

    , INTENSIVE CARE MEDICINE, Vol: 40, Pages: 202-210, ISSN: 0342-4642
  • Journal article
    Lyman M, Lloyd DG, Ji X, Vizcaychipi MP, Ma Det al., 2014,

    Neuroinflammation: The role and consequences

    , NEUROSCIENCE RESEARCH, Vol: 79, Pages: 1-12, ISSN: 0168-0102
  • Journal article
    Lax S, Wilson MR, Takata M, Thickett DRet al., 2014,

    Using a non-invasive assessment of lung injury in a murine model of acute lung injury

    , BMJ Open Respiratory Research, Vol: 1, ISSN: 2052-4439

    Arterial oxygen saturation has not been assessed sequentially in conscious mice as a direct consequence of an in vivo murine model of acute lung injury. Here, we report daily changes in arterial oxygen saturation and other cardiopulmonary parameters by using infrared pulse oximetry following intratracheal lipopolysaccharide (IT-LPS) for up to 9 days, and following IT-phosphate buffered saline up to 72 h as a control. We show that arterial oxygen saturation decreases, with maximal decline at 96 h post IT-LPS. Blood oxygen levels negatively correlate with 7 of 10 quantitative markers of murine lung injury, including neutrophilia and interleukin-6 expression. This identifies infrared pulse oximetry as a method to non-invasively monitor arterial oxygen saturation following direct LPS instillations.
  • Conference paper
    Soni S, Wilson MR, O'Dea K, Takata Met al., 2014,

    Microvesicles Are Sequentially Released From Different Intra-Alveolar Cells In A Mouse Model Of Acute Lung Injury

    , Publisher: AMER THORACIC SOC, ISSN: 1073-449X
  • Journal article
    Dunning JW, Merson L, Rohde GGU, Gao Z, Semple MG, Tran D, Gordon A, Olliaro PL, Khoo SH, Bruzzone R, Horby P, Cobb JP, Longuere K, Kellam P, Nichol A, Brett S, Everett D, Walsh TS, Hien T, Yu H, Zambon M, Ruiz-Palacios G, Lang T, Akhvlediani T, Hayden FG, Marshall J, Webb S, Angus DC, Shindo N, van der Werf S, Openshaw PJM, Farrar J, Carson G, Baillie JKet al., 2014,

    Open source clinical science for emerging infections

    , The Lancet Infectious Diseases, Vol: 14, Pages: 8-9, ISSN: 1473-3099
  • Journal article
    Palazzo S, James-Veldsman E, Wall C, Hayes M, Vizcaychipi Met al., 2014,

    Ventilation strategies in burn intensive care: A retrospective observational study

    , Burns & Trauma, Vol: 2, Pages: 29-29, ISSN: 2321-3868
  • Journal article
    Gordon AC, Mason AJ, Perkins GD, Ashby D, Brett SJet al., 2014,

    Protocol for a randomised controlled trial of VAsopressin versus Noradrenaline as Initial therapy in Septic sHock (VANISH)

    , BMJ Open, Vol: 4

    Introduction Vasopressin is an alternative vasopressor in the management of septic shock. It spares catecholamine use but whether it improves outcome remains uncertain. Current evidence suggests that it may be most effective if used early and possibly in conjunction with corticosteroids. This trial will compare vasopressin to noradrenaline as initial vasopressor in the management of adult septic shock and investigate whether there is an interaction of vasopressin with corticosteroids.Methods and analysis This is a multicentre, factorial (2×2), randomised, double-blind, placebo-controlled trial. 412 patients will be recruited from multiple UK intensive care units and randomised to receive vasopressin (0–0.06 U/min) or noradrenaline (0–12 µg/min) as a continuous intravenous infusion as initial vasopressor therapy. If maximum infusion rates of this first study drug are reached, the patient will be treated with either hydrocortisone (initially 50 mg intravenous bolus six-hourly) or placebo, before additional open-label catecholamine vasopressors are prescribed. The primary outcome of the trial will be the difference in renal failure-free days between treatment groups. Secondary outcomes include need for renal replacement therapy, survival rates, other organ failures and resource utilisation.Ethics and dissemination The trial protocol and information sheets have received a favourable opinion from the Oxford A Research Ethics Committee (12/SC/0014). There is an independent Data Monitoring and Ethics Committee and independent membership of the Trial Steering Committee including patient and public involvement. The trial results will be published in peer-reviewed journals and presented at national and international scientific meetings.Trial registration number: ISRCTN 20769191 and EudraCT 2011-005363-24.
  • Journal article
    Zhao H, Yoshida A, Xiao W, Ologunde R, O'Dea KP, Takata M, Tralau-Stewart C, George AJT, Ma Det al., 2013,

    Xenon treatment attenuates early renal allograft injury associated with prolonged hypothermic storage in rats

    , FASEB JOURNAL, Vol: 27, Pages: 4076-4088, ISSN: 0892-6638
  • Journal article
    Tatham K, Donaldson H, O'Dea K, Wakabayashi K, Marczin N, Takata Met al., 2013,

    Marginated monocytes play a central role in lung ischaemia-reperfusion injury in mice: Implications for lung transplantation

    , EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936

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