Critical care involves the care of the sickest patients in the hospital. Critically ill patients have usually been through a significant insult to their body (such as trauma, infection, burn) and have developed organ failure and require life-support. Critical Care is the largest theme bringing together clinicians and scientists from diverse backgrounds and includes collaborative research from hospitals throughout north-west London. Investigations range from evaluating biological mechanisms of organ failure through to the development of innovative technologies which allow the short-term and long-term support and recovery of organs.
Many people are exposed to the environment of an Intensive care unit (ICU) either personally or through a family member. It is often a life-changing event and our work aims to reduce this impact facilitating post-ICU recovery.
Research themes:
- Acute Respiratory Distress Syndrome (ARDS)
- Burn injury
- Extracorporeal life support
- Functional outcomes and health service research
- Sepsis
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Journal articleZhuang L, Yang T, Zhao H, et al., 2012,
The protective profile of argon, helium, and xenon in a model of neonatal asphyxia in rats
, CRITICAL CARE MEDICINE, Vol: 40, Pages: 1724-1730, ISSN: 0090-3493- Author Web Link
- Open Access Link
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- Citations: 104
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Journal articlePatel BV, Wilson MR, Takata M, 2012,
Resolution of acute lung injury and inflammation – a translational mouse model.
, European Respiratory Journal, Vol: 39, Pages: 1162-1170 -
Journal articleTavare AN, Perry NJS, Benzonana LL, et al., 2012,
Cancer recurrence after surgery: Direct and indirect effects of anesthetic agents*
, INTERNATIONAL JOURNAL OF CANCER, Vol: 130, Pages: 1237-1250, ISSN: 0020-7136- Author Web Link
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- Citations: 214
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Journal articleBertok S, Wilson MR, Morley PJ, et al., 2012,
Selective inhibition of intra-alveolar p55 TNF receptor attenuates ventilator-induced lung injury
, Thorax, Vol: 67, Pages: 244-251 -
Journal articleO'Callaghan DJP, Jayia P, Vaughan-Huxley E, et al., 2012,
An observational study to determine the effect of delayed admission to the intensive care unit on patient outcome
, CRITICAL CARE, Vol: 16, ISSN: 1364-8535- Author Web Link
- Open Access Link
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- Citations: 40
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Journal articleO'Dea KP, Dokpesi JO, Tatham KC, et al., 2011,
Regulation of monocyte subset proinflammatory responses within the lung microvasculature by the p38 MAPK/MK2 pathway
, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol: 301, Pages: L812-L821, ISSN: 1040-0605- Author Web Link
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- Citations: 29
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Journal articleScott AJ, O'Dea KP, O'Callaghan D, et al., 2011,
Reactive Oxygen Species and p38 Mitogen-activated Protein Kinase Mediate Tumor Necrosis Factor α-Converting Enzyme (TACE/ADAM-17) Activation in Primary Human Monocytes
, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 286, Pages: 35466-35476- Author Web Link
- Open Access Link
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- Citations: 78
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Journal articleO'Callaghan DJ, O'Dea KP, Gordon AC, et al., 2011,
MONOCYTE TACE ACTIVITY MAY RESPOND TO ENVIRONMENTAL STIMULI
, INTENSIVE CARE MEDICINE, Vol: 37, Pages: S258-S258, ISSN: 0342-4642 -
Journal articleO'Callaghan DJ, O'Dea KP, Gordon AC, et al., 2011,
MONOCYTE TACE ACTIVITY PROFILES ARE ALTERED BY INFLAMMATORY STIMULI
, INTENSIVE CARE MEDICINE, Vol: 37, Pages: S258-S258, ISSN: 0342-4642 -
Journal articleDorr AD, Wilson MR, Wakabayashi K, et al., 2011,
Sources of alveolar soluble TNF receptors during acute lung injury of different etiologies
, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 111, Pages: 177-184, ISSN: 8750-7587- Author Web Link
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- Citations: 14
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