Hand reaching into frozen samples


Group lead
Dr Ernesto Yague
+44 (0)20 7594 2802

Related themes

Disease areas

What we do

We investigate how cancer cells develop resistance to treatment and make it ineffective.

Why it is important

Chemotherapy is widely used in cancer treatment, but unfortunately a high proportion of patients develop resistance and the treatment is no longer effective. In many cases this has fatal consequences.

How it can benefit patients

Understanding the mechanisms by which cancer cells become resistant to therapy may help us to determine which patients may or may not benefit from certain therapies as well as in the development of novel therapeutic strategies.

Summary of current research

  • Control of drug resistance by microRNAs
  • miR-106b~25 cluster and EP300 as regulators of E-cadherin
  • EP300 in metaplastic breast cancer
  • miR-218 as regulator of apoptosis (via surviving)
  • miR-205 as regulator of FGF2


For patients


  • Dr Yunhui Hu - China Tianjin Breast Cancer Prevention, Treatment and Research Center
  • Prof. Parmjit Jat - UCL

PhD students

Current PhD students:

  • Roman Jugov 
  • Allison Hills 

Our researchers