BibTex format

author = {Grigg, J and Nibber, A and Paton, JY and Chisholm, A and Guilbert, TW and Kaplan, A and Turner, S and Roche, N and Hillyer, E and Price, DB and Collaborators, from REG Small Airways Working Group and Child Health Working Group includes and van, Aalderen WMC and Murray, CS and Phipatanakul, W and Sonnappa, S and Hoe, TO and Martin, RJ and Papi, A and Szefler, SJ and Skinner, D and McQueen, RB and Usmani, OS},
doi = {10.2147/JAA.S178531},
journal = {Journal of Asthma and Allergy},
title = {Matched cohort study of therapeutic strategies to prevent preschool wheezing/asthma attacks},
url = {},
volume = {11},
year = {2018}

RIS format (EndNote, RefMan)

AB - Background: An inhaled corticosteroid (ICS) or leukotriene receptor antagonist (LTRA) may prevent wheezing/asthma attacks in preschoolers with recurrent wheeze when added to short-acting β-agonist (SABA).Objective: The aim of this historical matched cohort study was to assess the effectiveness of these treatments for preventing wheezing/asthma attacks.Methods: Electronic medical records from the Optimum Patient Care Research Database were used to characterize a UK preschool population (1–5 years old) with two or more episodes of wheezing during 1 baseline year before first prescription (index date) of ICS or LTRA, or repeat prescription of SABA. Children initiating ICS or LTRA on the index date were matched 1:4 to those prescribed only SABA for age, sex, year of index prescription, mean baseline SABA dose, baseline attacks, baseline antibiotic prescriptions, and eczema diagnosis. Wheezing/asthma attacks (defined as asthma-related emergency attendance, hospital admission, or acute oral corticosteroid prescription) during 1 outcome year were compared using conditional logistic regression.Results: Matched ICS and SABA cohorts included 990 and 3,960 children, respectively (61% male; mean [SD] age 3.2 [1.3] years), and matched LTRA and SABA cohorts included 259 and 1,036 children, respectively (65% male; mean [SD] age 2.6 [1.2] years). We observed no significant difference between matched cohorts in the odds of a wheezing/asthma attack: ICS vs SABA, OR (95% CI) 1.01 (0.85–1.19) and LTRA vs SABA, OR (95% CI) 1.28 (0.96–1.72).Conclusion: We found no evidence that initiation of ICS or LTRA therapy is associated with fewer attacks during 1 outcome year than SABA alone for a heterogeneous group of preschool children with recurrent wheeze in the real-life clinical setting.
AU - Grigg,J
AU - Nibber,A
AU - Paton,JY
AU - Chisholm,A
AU - Guilbert,TW
AU - Kaplan,A
AU - Turner,S
AU - Roche,N
AU - Hillyer,E
AU - Price,DB
AU - Collaborators,from REG Small Airways Working Group and Child Health Working Group includes
AU - van,Aalderen WMC
AU - Murray,CS
AU - Phipatanakul,W
AU - Sonnappa,S
AU - Hoe,TO
AU - Martin,RJ
AU - Papi,A
AU - Szefler,SJ
AU - Skinner,D
AU - McQueen,RB
AU - Usmani,OS
DO - 10.2147/JAA.S178531
PY - 2018///
SN - 1178-6965
TI - Matched cohort study of therapeutic strategies to prevent preschool wheezing/asthma attacks
T2 - Journal of Asthma and Allergy
UR -
UR -
UR -
VL - 11
ER -