Molecular mechanisms of disease

Inhibition of the ATP synthase of Mycobacterium tuberculosis by the antibiotic bedaquiline
Inhibition of the ATP synthase of Mycobacterium tuberculosis by the antibiotic bedaquiline. Credit: Thomas Meier.

This theme focuses on the underlying molecular mechanisms of human diseases such as cancer, neurodegenerative disorders, genetic disorders of the musculoskeletal system, and bacterial infections. Research in the theme ranges from structural studies of target molecules to preclinical cancer models, with the aim of developing new modes of diagnosis or treatment.

Institutes, centres and initiatives

This Research Theme is associated to the following institutes, centres and initiatives:

Academic staff in this area

Dr Maruf Ali

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Dr Maruf Ali
Reader in Molecular and Structural Biology

Dr Michael J Baker

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Dr Michael J Baker
Assistant Teaching Fellow/Teaching Fellow

Dr Konstantinos Beis

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Dr Konstantinos Beis
Reader in Membrane Protein Structural Biology

Dr Doryen A Bubeck

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Dr Doryen A Bubeck
Reader in Structural Immunology

Dr Laurence Bugeon

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Dr Laurence Bugeon
Research Fellow

Dr Matthew A Child

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Dr Matthew A Child
Research Fellow (Sir Henry Dale Fellow)

Professor George K Christophides

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Professor George K Christophides
Professor of Infectious Diseases & Immunity

Professor Stephen Curry

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Professor Stephen Curry
Professor of Structural Biology, Associate Provost (EDI)

Dr Alessia David

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Dr Alessia David
Lecturer in Bioinformatics and Data Intensive Biology

Professor Daniel M Davis

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Professor Daniel M Davis
Head of Department of Life Sciences, Chair in Immunology

Professor Alfonso De Simone

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Professor Alfonso De Simone
Visiting Professor

Professor Marc S Dionne

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Professor Marc S Dionne
Professor of Innate Immunity

Dr Nadia Guerra

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Dr Nadia Guerra
Senior Lecturer

Dr Anita C Hall

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Dr Anita C Hall
Senior Teaching Fellow

Professor Erhard Hohenester

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Professor Erhard Hohenester
Professor of Structural Matrix Biology

Dr Theodoros Karamanos

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Dr Theodoros Karamanos
Lecturer (Wellcome Trust & Royal Society

Dr David Mann

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Dr David Mann
Reader in Cell Cycle Control

Professor Thomas K Meier

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Professor Thomas K Meier
Chair in Structural Biology

Dr Atieme Joseph Ogbolosingha

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Dr Atieme Joseph Ogbolosingha
Teaching Fellow

Dr Marco Trizzino

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Dr Marco Trizzino
Senior Lecturer in Developmental Genomics