Two researchers in lab

What we do

Our research focuses on understanding how changes to the function of the constituent cells of the heart lead to the clinical manifestations of disease.  We use this knowledge to guide improvements in diagnostic procedures, provide better clinical management and generate novel treatments. 

Why it is important

Heart and circulatory disease kills more than one in four people in the UK (causing 26 per cent of all deaths).  This translates to nearly 160,000 deaths each year, an average of 435 people each day or one death every three minutes. By understanding disease processes and discovering new therapies we are endeavouring to revolutionise the treatment of heart diseases.

Impact of our research

Through our studies of the changes in the diseased heart, we have brought developments to the clinic with new electrophysiological methods and the first UK cardiac gene therapy clinical trials. We have discovered new mechanisms underlying chemotherapeutic cardiomyopathy and Takotsubo, or stress cardiomyopathy, and have identified a cell signalling protein called MAP4K4 as a trigger for cardiac cell death. Our BHF Cardiovascular Regenerative Medicine Centre is currently developing engineered heart tissue made from stem cell-derived cardiac muscle cells for grafting into damaged hearts. Novel biomaterials are being combined with the stem cells to produce an optimised functional cardiac patch. We also use these stem cell-derived human cardiac muscle cells as disease-in-a-dish models to understand the changes induced by human genetic variants.

Vardiac function videos

Summary of current research

The section brings together people with scientific and clinical backgrounds who have a breadth of expertise in the biochemistry, biophysics, immunology, physiology and pharmacology of the heart.  They have strong cross-faculty interdisciplinary collaborations with Bioengineering, Computing, (notably through the ElectroCardioMaths programme), Physics (Photonics) and Materials.

Current projects

  • Developing new imaging methods, allowing nanoscale resolution of cell structure to 3D visualisation of live heart tissue and cells.
  • Evaluating conductive polymers to help stem cell-derived cardiac myocytes integrate safely into the damaged heart.
  • Exploiting ultrathin slices of cardiac muscle to understand rhythm abnormalities, the integration of stem cells into the working myocardium and the effects of mechanical strain   
  • Generating gene edited and patient-derived pluripotent stem cells to help understand cardiac dysfunction and rhythm disturbances in hypertrophic cardiomyopathy. 
  • Improving our understanding of transcriptional events, cellular metabolic pathways and the epigenetic mechanisms that regulate cell differentiation.
  • Exploring the paracrine effects of cell transplantation. 
  • Investigating the interactions between the immune and cardiovascular systems.
  • Combining state-of-the-art clinical electrophysiology with the mathematical and computing sciences to improve the diagnosis and treatment of complex cardiac arrhythmias.
  • Studying mutations in POPDC cAMP effector proteins that are associated with cardiac arrhythmias.
  • Examining the cellular and molecular drivers of cardiac remodelling in healthy and failing human hearts.
  • Investigating the relationship between exosomes (extracellular vesicles) and the development of cardiac pathologies and possible muscle repair pathways.

Connections


Our researchers

Dr Daniel J Stuckey

Image Description

Dr Daniel J Stuckey
Honorary Research Fellow