Blast Injury Outcome Study in Armed Forced Personnel (BIOSAP)


In collaboration with the Ministry of Defence and the Royal College of Surgeons of England we are investigating the effect of blast on the brain. Participants are soldiers who have suffered a blast traumatic brain injury (bTBI) as a result of improvised explosive devices (IEDs) in Iraq and Afghanistan. This study is using positron emission tomography (PET) and magnetic resonance imaging (MRI) to investigate chronic neuroinflammation and neurodegeneration and its relationship to brain structure and function. This is the first PET study investigating neuroinflammation following blast trauma in a military population and will inform our understanding of blast-related neuropathology in future conflicts.

Principal investigators

Researchers involved

  • Amy Jolly
  • Stuart Roberts


  • UK Ministry of Defence 
  • UK Royal College of Surgeons